What does PML mean in UNCLASSIFIED

PML can cause symptoms such as vision loss, weakness in the arms and legs, problems with thinking and memory, personality changes, difficulty speaking or understanding speech, and confusion.

The diagnosis of PML requires a combination of clinical findings, magnetic resonance imaging (MRI) scans of the brain to identify white matter lesions that are consistent with PML, and a lumbar puncture which identifies the presence of JC virus within the spinal fluid.

Treatment for PML depends on factors such as age, overall health status, severity of symptoms and the presence of underlying medical conditions. Depending on the individual's condition treatment may involve antiviral medications or therapy to address motor deficits caused by nerve damage. There is no cure for this illness but supportive care can be given to manage symptoms and improve quality of life.

Yes, complications from this disorder can include cognitive decline resulting in dementia-like symptoms, seizures, breathing problems due to respiratory muscle weakening caused by nerve damage in the brainstem area and death due to severe neurological decline.

This disorder is very rare and tends to occur only in individuals with weakened immune systems due to specific medical treatments or diseases such as AIDS/HIV infection or cancer. It has been estimated that less than 1% of all cases are reported annually worldwide.