What does DCC mean in CANCER
Deleted in Colon Cancer (DCC) is a gene located on chromosome 18q21.31. It encodes a protein that plays a crucial role in regulating cell growth and apoptosis. DCC mutations are commonly found in colorectal cancers, where they contribute to tumor progression and metastasis.
DCC meaning in Cancer in Medical
DCC mostly used in an acronym Cancer in Category Medical that means Deleted in Colon Cancer
Shorthand: DCC,
Full Form: Deleted in Colon Cancer
For more information of "Deleted in Colon Cancer", see the section below.
What does DCC Stand for?
DCC stands for Deleted in Colon Cancer.
DCC Meaning in MEDICAL
DCC is a tumor suppressor gene that acts as a negative regulator of cell growth. It encodes a transmembrane protein that interacts with netrin-1, a secreted protein involved in axon guidance during nervous system development. Upon binding to netrin-1, DCC undergoes phosphorylation and triggers intracellular signaling cascades that inhibit cell proliferation and promote apoptosis.
DCC Mutations and Cancer
DCC mutations are frequently observed in colorectal cancers, accounting for approximately 5-15% of cases. These mutations can result in either loss of function or gain of function of the DCC protein. Loss-of-function mutations lead to impaired netrin-1 signaling, resulting in increased cell proliferation and decreased apoptosis, contributing to tumorigenesis.
Final Words: DCC is a critical gene involved in cell growth regulation and apoptosis. Mutations in DCC are associated with the development of colorectal cancers. Understanding the role of DCC in cancer biology is essential for developing targeted therapies for colorectal cancer patients.
DCC also stands for: |
|
| All stands for DCC |