What does CIM mean in UNCLASSIFIED
CIM (Carbapenem Inactivation Method) is a rapid diagnostic test used to detect carbapenemase-producing bacteria, which are bacteria that have developed resistance to carbapenem antibiotics, one of the last-line antibiotics used to treat serious infections.
CIM meaning in Unclassified in Miscellaneous
CIM mostly used in an acronym Unclassified in Category Miscellaneous that means Carbapenem Inactivation Method
Shorthand: CIM,
Full Form: Carbapenem Inactivation Method
For more information of "Carbapenem Inactivation Method", see the section below.
What is CIM?
CIM is a phenotypic test that involves exposing a bacterial isolate to a carbapenem antibiotic (usually imipenem or meropenem) with and without the addition of a carbapenemase inhibitor (such as ethylenediaminetetraacetic acid or EDTA). The difference in the susceptibility results between the two conditions indicates the presence or absence of carbapenemase production.
Procedure
The CIM test is typically performed as follows:
- Disk diffusion method: Two antibiotic disks are placed on an agar plate containing the bacterial isolate. One disk is impregnated with a carbapenem antibiotic, while the other disk contains the carbapenem antibiotic and the carbapenemase inhibitor.
- Gradient diffusion method: A gradient of carbapenem concentrations is created on an agar plate, with one end containing a high concentration of the antibiotic and the other end containing a low concentration. The bacterial isolate is streaked perpendicular to the gradient.
Interpretation
- A positive CIM test is indicated by a significant difference in the susceptibility zone size or inhibition zone diameter between the antibiotic-only disk/strip and the antibiotic-inhibitor disk/strip. This difference suggests that the isolate is producing carbapenemase.
- A negative CIM test indicates that the isolate is not producing carbapenemase.
Significance
CIM is an important diagnostic tool for the rapid detection of carbapenemase-producing bacteria. Early identification of these organisms is crucial for implementing appropriate infection control measures and selecting the most effective antibiotics for treatment.
Essential Questions and Answers on Carbapenem Inactivation Method in "MISCELLANEOUS»UNFILED"
What is the Carbapenem Inactivation Method (CIM)?
The Carbapenem Inactivation Method (CIM) is a laboratory technique used to detect the presence of carbapenemases, enzymes produced by bacteria that can break down carbapenem antibiotics. Carbapenems are a class of antibiotics that are commonly used to treat severe bacterial infections.
How is the CIM performed?
The CIM is performed by mixing a bacterial isolate with a carbapenem antibiotic and a chromogenic cephalosporin, which is a compound that changes color in the presence of carbapenemase activity. If carbapenemase is present, it will break down the carbapenem antibiotic, allowing the chromogenic cephalosporin to change color. A color change indicates a positive CIM result, suggesting the presence of carbapenemase production.
What are the limitations of the CIM?
The CIM has some limitations. It can be affected by factors such as the inoculum size, the incubation time, and the type of carbapenemase present. Additionally, the CIM may not be able to detect all carbapenemase-producing bacteria, particularly those that produce low levels of carbapenemase.
How is the CIM used in clinical practice?
The CIM is a useful tool for screening bacterial isolates for carbapenemase production. A positive CIM result can help guide antibiotic selection and infection control measures. However, it is important to note that the CIM is not a definitive test for carbapenemase production, and further testing may be necessary to confirm the presence of carbapenemase genes.
What are the advantages of using the CIM?
The CIM has several advantages. It is a relatively simple and inexpensive test to perform. It can be performed in a routine clinical laboratory setting. The results are typically available within a few hours, making it a rapid screening tool.
Final Words: CIM is a reliable and widely used method for detecting carbapenemase-producing bacteria. It provides valuable information for guiding clinical management and preserving the efficacy of carbapenems as a critical class of antibiotics.
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