What does ESL mean in UNCLASSIFIED
ESL, short for E Selectin Ligand, is a protein expressed on the surface of leukocytes, allowing these cells to bind to inflamed endothelium and extravasate into tissues. ESL is a member of the Sialyl Lewis X (sLex) family of carbohydrate antigens and is recognized by the adhesion molecule E-selectin, which is expressed on activated endothelial cells. The interaction between ESL and E-selectin plays a critical role in the recruitment of leukocytes to sites of inflammation.
ESL meaning in Unclassified in Miscellaneous
ESL mostly used in an acronym Unclassified in Category Miscellaneous that means E Selectin Ligand
Shorthand: ESL,
Full Form: E Selectin Ligand
For more information of "E Selectin Ligand", see the section below.
ESL Structure and Function
ESL is a glycoprotein that contains a core protein of approximately 140 amino acids and two N-linked glycosylation sites. The core protein is highly conserved among different species, while the glycosylation pattern can vary. The carbohydrate moiety of ESL is responsible for its binding to E-selectin.
Role in Leukocyte Adhesion and Inflammation
ESL is expressed on the surface of neutrophils, monocytes, and lymphocytes. When these cells encounter activated endothelial cells expressing E-selectin, ESL binds to the adhesion molecule, initiating a cascade of events that leads to leukocyte adhesion and transmigration. This process is essential for the recruitment of leukocytes to sites of inflammation, where they can participate in the immune response.
Essential Questions and Answers on E Selectin Ligand in "MISCELLANEOUS»UNFILED"
What is ESL (E Selectin Ligand)?
ESL, also known as CD62E, is a cell adhesion molecule expressed on the surface of leukocytes and endothelial cells. It plays a crucial role in the inflammatory response by facilitating the binding of leukocytes to activated endothelial cells, allowing them to extravasate into tissues during inflammation.
What is the function of ESL in inflammation?
ESL interacts with E-selectin, an adhesion molecule expressed on activated endothelial cells, to mediate the initial binding of leukocytes to the endothelium during inflammation. This interaction allows leukocytes to roll along the endothelium, which is essential for their subsequent adhesion and transmigration into tissues.
What are the clinical implications of ESL deficiency?
ESL deficiency is a rare genetic disorder characterized by impaired leukocyte adhesion to the endothelium. This leads to recurrent infections due to the reduced ability of leukocytes to migrate into tissues and fight infections.
How is ESL deficiency diagnosed?
ESL deficiency is typically diagnosed through laboratory tests that measure the expression or function of ESL on leukocytes. These tests may include flow cytometry or functional assays that assess the ability of leukocytes to adhere to activated endothelial cells.
What are the treatment options for ESL deficiency?
Treatment options for ESL deficiency may include prophylactic antibiotics to prevent infections, as well as hematopoietic stem cell transplantation or gene therapy in severe cases.
Final Words: ESL is a crucial adhesion molecule that plays a key role in leukocyte recruitment and inflammation. Understanding the structure and function of ESL can provide insights into the development of therapeutic strategies for inflammatory diseases.
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