What does SFK mean in UNCLASSIFIED
SFK stands for Src family kinase. SFKs are a group of non-receptor tyrosine kinases that play a crucial role in various cellular processes, including cell growth, differentiation, and migration. They are named after the prototype member of the family, Src (v-Src), which was originally identified as the oncogene responsible for the Rous sarcoma virus.
SFK meaning in Unclassified in Miscellaneous
SFK mostly used in an acronym Unclassified in Category Miscellaneous that means Src family kinase
Shorthand: SFK,
Full Form: Src family kinase
For more information of "Src family kinase", see the section below.
SFK Structure and Function
SFKs are composed of several domains, including an N-terminal SH4 domain, a central SH3 domain, and a C-terminal kinase domain. The SH4 and SH3 domains are involved in protein-protein interactions, while the kinase domain is responsible for phosphorylating tyrosine residues on target proteins.
SFKs are activated by a variety of stimuli, including growth factors, cytokines, and integrins. Upon activation, they phosphorylate various substrates, including other kinases, adaptors, and transcription factors. These phosphorylation events can lead to changes in gene expression, cell cycle progression, and cytoskeletal organization.
Role in Cancer
SFKs have been implicated in the development and progression of various types of cancer. They are often overexpressed or hyperactivated in cancer cells, where they can promote cell growth, survival, and migration. SFKs can also contribute to cancer progression by inducing angiogenesis, invasion, and metastasis.
Essential Questions and Answers on Src family kinase in "MISCELLANEOUS»UNFILED"
What is Src family kinase (SFK)?
SFK is a group of non-receptor tyrosine kinases that play a crucial role in various cellular processes, including cell growth, differentiation, migration, and survival.
What are the different types of SFKs?
There are nine known members of the SFK family in humans: Src, Fyn, Yes, Lyn, Hck, Lck, Blk, Fgr, and Yrk. Each SFK has a distinct expression pattern and function.
How are SFKs activated?
SFKs are activated by various mechanisms, including ligand binding to receptor tyrosine kinases, integrin engagement, and G protein-coupled receptor activation. Activation leads to phosphorylation of a conserved tyrosine residue within the activation loop, resulting in conformational changes and increased kinase activity.
What are the substrates of SFKs?
SFKs phosphorylate a wide range of substrates, including other kinases, adapter proteins, and transcription factors. By phosphorylating these substrates, SFKs regulate various cellular processes, including cell cycle progression, cytoskeletal organization, and gene expression.
Are SFKs involved in cancer?
Yes, SFKs have been implicated in the development and progression of several types of cancer. Aberrant SFK activity can lead to increased cell proliferation, invasion, angiogenesis, and resistance to therapy.
How are SFKs targeted for cancer therapy?
Several approaches are being developed to target SFKs for cancer therapy. These include small molecule inhibitors, monoclonal antibodies, and peptide inhibitors. Targeting SFKs has shown promising results in preclinical models and clinical trials.
Final Words: SFKs are important regulators of cellular processes and play a significant role in cancer development. Targeting SFKs with specific inhibitors has emerged as a promising therapeutic strategy for the treatment of various types of cancer.
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