What does AL mean in CLINICAL MEDICINE
AL stands for Artemether-lumefantrin, a fixed-dose combination medication used to treat uncomplicated malaria. It is one of the most commonly used antimalarial treatments worldwide.
AL meaning in Clinical Medicine in Medical
AL mostly used in an acronym Clinical Medicine in Category Medical that means Artemether-lumefantrin
Shorthand: AL,
Full Form: Artemether-lumefantrin
For more information of "Artemether-lumefantrin", see the section below.
What is AL?
AL is a combination of two antimalarial drugs:
- Artemether: A fast-acting artemisinin derivative that rapidly kills malaria parasites.
- Lumefantrin: A long-acting partner drug that prevents the recurrence of malaria.
How does AL Work?
AL works by targeting different stages of the malaria parasite's life cycle:
- Artemether kills the parasites in the blood within 24 hours.
- Lumefantrin prevents the development of new parasites in the liver.
Effectiveness
AL is highly effective in treating uncomplicated malaria, with cure rates of over 95%. It is particularly effective against Plasmodium falciparum, the most common and dangerous malaria parasite.
Dosage and Administration
AL is taken orally, once daily, for three days. The recommended dosage varies depending on body weight.
Side Effects
AL is generally well-tolerated, but some common side effects include:
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
Contraindications
AL should not be used in individuals who:
- Have a known allergy to artemether or lumefantrin
- Are pregnant or breastfeeding
- Have severe liver or kidney disease
Essential Questions and Answers on Artemether-lumefantrin in "MEDICAL»CLINICAL"
What is Artemether-lumefantrin (AL)?
Artemether-lumefantrin (AL) is a combination antimalarial medication used to treat uncomplicated malaria caused by Plasmodium falciparum parasites. It combines two active ingredients: artemether, an artemisinin derivative, and lumefantrine, a long-acting blood schizonticide.
How does AL work?
Artemether rapidly reduces the parasite load in the blood, while lumefantrine clears the remaining parasites and prevents reinfection for up to four weeks. Artemether is effective against all stages of the malaria parasite, including the gametocytes that can be transmitted to mosquitoes.
Is AL effective against all types of malaria?
AL is only effective against uncomplicated malaria caused by P. falciparum parasites. It is not effective against malaria caused by other species of Plasmodium, such as P. vivax or P. ovale.
How is AL administered?
AL is taken orally, once daily, for three days. The tablets should be taken with food to enhance absorption.
What are the side effects of AL?
Common side effects of AL include nausea, vomiting, abdominal pain, diarrhea, headache, and dizziness. Severe side effects are rare but can include liver damage and cardiac arrhythmias.
Who should not take AL?
AL should not be taken by people with severe kidney or liver disease, or by those taking other medications that can interact with AL, such as ketoconazole or rifampicin.
Is AL safe for pregnant women?
AL is generally considered safe for use during pregnancy, but it should be used with caution in the first trimester.
Final Words: AL is a safe and effective medication for the treatment of uncomplicated malaria. It is widely used and has been shown to reduce the risk of severe malaria and death. However, it is important to consult with a healthcare professional before taking AL to discuss potential side effects and contraindications.
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