What does VIPR mean in HUMAN GENOME

The expression of VIP receptors are found throughout several organs including the gastrointestinal tract, heart, airways and reproductive organs. They are also found on the surface of certain types of cells such as neurons, macrophages and fibroblasts.

Vasoactive Intestinal Peptide (VIP) receptors couple to G proteins when activated by its ligand (Vasoactive Intestinal Peptide), triggering a wide variety of cellular responses depending on cell type or tissue context. Generally these include increased cortisol secretion from the adrenal glands, increased smooth muscle relaxation which helps reduce vascular resistance and increase blood supply to tissues around it as well as decreased proinflammatory cytokines from macrophages.

When VIP binds to the receptor, it causes conformational changes in the structure of G proteins that lead to downstream cellular signaling events resulting in either an inhibitory or stimulatory response depending on cell context. This binding event triggers a cascade of events inside the cell that result in a number of physiological effects.

Once bound, VIP stimulates a cascade of downstream pathways which cause changes within the cell leading to physiological effects like increased cortisol secretion from the adrenal glands or increased smooth muscle relaxation both helping regulate local tissue blood flow.

Yes. Dysfunctioning VIP receptors can be associated with some forms of Inflammatory Bowel Disease (IBD), kidney disease and coronary artery disease (known as atherosclerosis). Additionally they can also be associated with certain types of cancer such as colorectal cancer and pancreatic cancer.

Agonists are molecules that bind to a receptor site on a target cell membrane and activate it by mimicking naturally occurring endocrine hormones. In this case, vasoactive intestinal peptides (VIPs) are natural agonists for VPI receptors and can stimulate them causing biological effects like increased cortisol secretion or increased smooth muscle relaxation