What does VIPR mean in HUMAN GENOME
A Vasoactive Intestinal Peptide (VIP) receptor is a type of G protein-coupled receptor that binds the hormone VIP and mediates its action. It is expressed in various organs, most notably the GI tract and blood vessels, where it plays an important role in controlling local intestinal blood flow, regulating intestinal secretions, and modulating inflammation.
VIPR meaning in Human Genome in Medical
VIPR mostly used in an acronym Human Genome in Category Medical that means Vasoactive Intestinal Peptide Receptor
Shorthand: VIPR,
Full Form: Vasoactive Intestinal Peptide Receptor
For more information of "Vasoactive Intestinal Peptide Receptor", see the section below.
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Essential Questions and Answers on Vasoactive Intestinal Peptide Receptor in "MEDICAL»GENOME"
What is a Vasoactive Intestinal Peptide Receptor?
Where are Vasoactive Intestinal Peptide Receptors located?
The expression of VIP receptors are found throughout several organs including the gastrointestinal tract, heart, airways and reproductive organs. They are also found on the surface of certain types of cells such as neurons, macrophages and fibroblasts.
What does a Vasoactive Intestinal Peptide Receptor do?
Vasoactive Intestinal Peptide (VIP) receptors couple to G proteins when activated by its ligand (Vasoactive Intestinal Peptide), triggering a wide variety of cellular responses depending on cell type or tissue context. Generally these include increased cortisol secretion from the adrenal glands, increased smooth muscle relaxation which helps reduce vascular resistance and increase blood supply to tissues around it as well as decreased proinflammatory cytokines from macrophages.
How does VIP interact with the receptor?
When VIP binds to the receptor, it causes conformational changes in the structure of G proteins that lead to downstream cellular signaling events resulting in either an inhibitory or stimulatory response depending on cell context. This binding event triggers a cascade of events inside the cell that result in a number of physiological effects.
What happens once VIP binds to its receptor?
Once bound, VIP stimulates a cascade of downstream pathways which cause changes within the cell leading to physiological effects like increased cortisol secretion from the adrenal glands or increased smooth muscle relaxation both helping regulate local tissue blood flow.
Are there any diseases associated with dysfunctioning VIP receptors?
Yes. Dysfunctioning VIP receptors can be associated with some forms of Inflammatory Bowel Disease (IBD), kidney disease and coronary artery disease (known as atherosclerosis). Additionally they can also be associated with certain types of cancer such as colorectal cancer and pancreatic cancer.
What is an agonist for VIP Receptor?
Agonists are molecules that bind to a receptor site on a target cell membrane and activate it by mimicking naturally occurring endocrine hormones. In this case, vasoactive intestinal peptides (VIPs) are natural agonists for VPI receptors and can stimulate them causing biological effects like increased cortisol secretion or increased smooth muscle relaxation
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