What does RRM mean in HUMAN GENOME
RRM stands for Rna Recognition Motif. It is a nucleic acid-binding domain that binds to target RNA molecules and plays an important role in the regulation of gene expression. RRMs are found in many proteins involved in transcription, splicing, and ribosome biogenesis. They consist of at least one alpha helix, two Beta Sheets, and loops. The RRM binds to its target through hydrogen bonding interactions with RNA nucleotides. In this way, it can recognize specific sequences within the target molecule and bind to them with high affinity and selectivity
RRM meaning in Human Genome in Medical
RRM mostly used in an acronym Human Genome in Category Medical that means Rna Recognition Motif
Shorthand: RRM,
Full Form: Rna Recognition Motif
For more information of "Rna Recognition Motif", see the section below.
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Essential Questions and Answers on Rna Recognition Motif in "MEDICAL»GENOME"
What is a RRM?
A RRM or Rna Recognition Motif is a protein domain that binds to specific RNA sequences in order to recognize and regulate RNAs. It plays an important role in various cellular processes and functions.
How does RRM recognize RNAs?
RRMs are able to recognize specific sequences of RNA molecules through their unique binding preference. The RRM typically bind to the major groove of the RNA helix, which is composed of four different types of hydrogen bond interactions. These interactions enable recognition between the two molecules and allow for regulatory effects on the RNA molecule.
What are some examples of proteins with RRMs?
Some proteins with RRMs include KSRP (KH-type splicing regulatory protein), LIN-54, RBFOX1, as well as other proteins involved in transcriptional regulation, such as ELAV1 and PTBP1.
How do RRMs affect gene expression?
RRMs can play an important role in controlling gene expression, because they can affect the stability, splicing, and transport of messenger RNAs (mRNAs). By binding to specific sequences on mRNAs, the RRM can either promote or repress mRNA processing and transport into the cytoplasm. This can ultimately result in changes in observed phenotypes due to altered gene expression levels.
Are there any diseases linked to mutations in proteins with RRMs?
Yes, mutations have been identified within proteins containing RRMs which have been linked to various human diseases including cancer, Alzheimer's disease, muscular dystrophy and retinitis pigmentosa. Specifically, loss-of-function mutations within elav-like 1 (ELAVL1) have been linked to X-linked spinal muscular atrophy type 3 (SMAX3). Furthermore, a missense mutation within ELAVL4 has been associated with familial late-onset Alzheimer's disease (LOAD).
Is there any software for analyzing RNAs for potential binding sites for RMM's?
Yes! There are several available tools that can be used for prediction of potential binding sites for RMM's on RNAs; these tools often employ algorithms based on phylogenetic conservations across species or secondary structure conservation among families of related genes. Examples include MEME Suite, Prosite Scan Tool, TatianaRNAWebServer, and Quorum.
Are there any Structural Characteristics associated with RMM's?
Yes! Structurally speaking many RMM's feature a β-β sandwich motif made up of two anti parallel β sheets connected via α helices known as BXH motifs; this characteristic motif along with several conserved residues both inside and outside this region allows them to bind single stranded rna molecules specifically.
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