What does PLC mean in BIOLOGY

The activity of PLC is regulated by different factors, such as hormones and neurotransmitters, which bind to their respective receptors on the cell surface and activate the proteins associated with them. These proteins then trigger a cascade of biochemical processes that ultimately lead to activation of PLC.

PLC controls a variety of biological processes, including cell proliferation, differentiation, apoptosis, metabolism and stress responses. In particular, it plays a pivotal role in signal transduction pathways involved in hormone-regulated development and homeostasis.

Dysregulation of PLC activity has been linked to various diseases, including diabetes mellitus type 2, Parkinson's disease and Alzheimer's disease. Disruption of normal phospholipid metabolism may also be responsible for certain forms of cancer and neurological disorders.

Several other types of enzymes interact with PLC to regulate its activity. These include kinases such as protein kinase C (PKC) and tyrosine kinase (TK). Additionally, G-proteins act on catalytic domains contained within specific forms of PLC to affect its function.

Inositol triphosphate (IP3) is produced when phospholipids are hydrolyzed by activated forms of phospholipase C enzyme family member in response to extracellular signals or hormones. IP3 then binds to its receptor located on the endoplasmic reticulum membrane where it triggers calcium release from the internal stores resulting in increased cytoplasmic calcium concentrations leading ultimately to downstream effects on gene expression or cellular metabolism.

Yes, Fas ligand induces apoptosis through a series of events culminating in activation or stimulationof phosphorylated PI3K which leads ultimately tooverproductionof IP3 thus triggering calcium release from internal stores which causes disruptionof mitochondrialmembranesresultinginsurfacematurationoftheapoptosomeformaximumcaspasemediatedcell death.