What does MPSS mean in UNCLASSIFIED

Massively Parallel Signature Sequencing (MPSS) is a type of high throughput DNA sequencing technology used to obtain transcription-wide data from large volumes of small cDNA molecules.

The advantages of MPSS include being able to quickly and accurately identify gene expression patterns at the single-cell level, having a low background noise while providing high signal intensity, and having accurate quantification capabilities due to its homogeneous nature.

Any types of liquid samples such as whole blood, plasma, serum, or other biological fluids can be used for MPSS. Additionally, cells lysed in lysis buffer and tissue homogenates also work well.

Compared to other traditional Sanger sequencing methods, MPSS offers comprehensive coverage across entire transcriptomes with significantly improved accuracy and sensitivity. Additionally, it allows researchers to rapidly quantify transcripts present in different sample types while also identifying rare transcripts that would otherwise remain undetected.

After performing an MPSS experiment, researchers can analyze the data obtained in order to observe specific changes in gene expression which may give insight into various biological functions and processes occurring within the sample. Additionally, this data can be useful for developing predictive models about various diseases or conditions related to those processes.