What does APML mean in PHYSIOLOGY
Acute promyelocytic leukemia (APML) is a rare and severe form of acute myeloid leukemia (AML) that affects the body’s white blood cells. APML is caused by changes in the genes controlling the development of immature white blood cells, called promyelocytes. These abnormal cells can build up in the bone marrow and interfere with the production of healthy blood cells. APML is a highly treatable type of leukemia, with more than 85% of patients achieving complete remission with treatment.
APML meaning in Physiology in Medical
APML mostly used in an acronym Physiology in Category Medical that means Acute Promyelocytic Myelogneous Leukemia
Shorthand: APML,
Full Form: Acute Promyelocytic Myelogneous Leukemia
For more information of "Acute Promyelocytic Myelogneous Leukemia", see the section below.
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Symptoms
The most common symptom associated with APML is bleeding from small cuts or wounds due to decreased platelet levels in the bloodstream caused by overcrowding of immature white blood cells in bone marrow. Other symptoms may include fatigue, weakness, chest pain, weight loss, fever, easy bruising or bleeding, frequent infections and night sweats due to anemia — a low concentration of red blood cells — caused by overcrowding in bone marrow as well.
Treatment
Treatment for APML typically involves chemotherapy drugs combined with targeted therapy drugs such as arsenic trioxide or all-trans retinoic acid (ATRA). These two agents work together to create apoptosis — programmed cell death — among abnormal promyelocytes thereby reducing their numbers within bone marrow while simultaneously stimulating normal maturation among healthy ones. Additional chemotherapy agents may be prescribed depending on patient age or response to treatment. Radiation therapy may also be used if certain areas contain large concentrations of abnormal promyelocytes that cannot be addressed solely through drug treatment alone; however this approach should be used cautiously as radiation carries its own risks including long-term side effects such as infertility or secondary cancers which could develop many years down the line.
Essential Questions and Answers on Acute Promyelocytic Myelogneous Leukemia in "MEDICAL»PHYSIOLOGY"
What is APML?
Acute promyelocytic leukemia (APML) is a form of acute myeloid leukemia, a cancer of the white blood cells. APML is characterized by an overabundance of immature white cells called promyelocytes in the bone marrow and blood.
What are common symptoms of APML?
Common symptoms of APML include feeling weak, tiredness, shortness of breath, easy bruising and bleeding, swollen lymph nodes or gums, fever and night sweats.
How is APML Diagnosed?
To diagnose APML your doctor will take a complete medical history and may order tests such as blood count tests, bone marrow examinations and other tests to look for abnormal growths or abnormalities in the blood.
Is there any treatment available for APML?
Yes, there are several treatment options available for people with APML including chemotherapy drugs such as arsenic trioxide or all-trans retinoic acid combined with certain types of chemotherapy drugs. Surgery may also be performed to remove any tumors that have formed in the bone marrow.
What is remission in terms of APML?
In terms of APML remission means that all symptoms have disappeared and there are no more abnormal white cells detected in the body. This could be temporary or permanent depending on the type of treatment given.
What happens if my condition does not go into remission?
If your condition does not go into remission after undergoing treatment then you may need additional treatments or therapies to reduce your disease burden further. Your doctor will discuss options with you to determine what is best for your individual situation.
Can I still live a normal life if I have been diagnosed with APML?
Yes, many patients with APML go on to live normal lives following their diagnosis and successful treatment plan. It’s important to keep up with regular checkups and medication dosages for continued health and wellbeing.
Is it possible for other family members to develop this disorder too?
Although it is rare for this disorder to be passed down through families it can happen so it’s important to talk to your doctor if any other family members have experienced similar symptoms or diagnoses before making any decision about treatment options or lifestyle changes.
Final Words:
In summary, acute promyelocytic leukemia (APML) is a rare form of acute myeloid leukemia characterized by changes in the genes controlling maturation processes within myeloid progenitor cells resulting in uncontrolled reproduction among immature precursors known as promyelocytes causing crowding out within bone marrow leading to anemia (lowered red cell count), thrombocytopenia (lowered platelet count), fatigue, weakness and other adverse symptoms if left untreated. Treatment involves combining Apoptosis inductive agents such as ATRA or arsenic trioxide along with traditional chemotherapy medications depending on age/response to treatment and radiation therapy for persistent localized collections not addressed through drug therapies alone although these strategies present their own risks including secondary malignancies developing late down the line.
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