What does HLAR mean in LABORATORY
HLAR stands for High-Level Aminoglycoside-Resistant, and it refers to bacteria that have developed a resistance to certain antibiotics known as aminoglycosides. Resistance to this class of antibiotics has been an increasing public health concern as it limits treatment options against bacterial infections.
HLAR meaning in Laboratory in Medical
HLAR mostly used in an acronym Laboratory in Category Medical that means High-Level Aminoglycoside-Resistant
Shorthand: HLAR,
Full Form: High-Level Aminoglycoside-Resistant
For more information of "High-Level Aminoglycoside-Resistant", see the section below.
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Definition
HLAR is a type of drug resistance in which bacteria become able to tolerate high levels of aminoglycoside antibiotics such as gentamicin, amikacin, tobramycin and kanamycin. These antibiotics are commonly used to treat serious infections caused by Gram-negative bacteria such as E. coli, Pseudomonas aeruginosa and Proteus species.
Mechanism
The mechanism behind HLAR is the production of enzymes known as aminoglycoside modifying proteins (AMP) or 16S rRNA methylase enzymes, which can modify or enzymatically deactivate the structure or activity of the antibiotic molecules, thus rendering them ineffective in killing the bacteria.
Clinical Implications
HLAR can cause therapy failure resulting in prolonged illness and increased costs associated with treating already resistant bacteria. Treatment failure can also lead to higher morbidity and mortality due to more severe infection caused by these resistant organisms. The spread of HLAR should therefore be monitored carefully in order to limit its further dissemination.
Essential Questions and Answers on High-Level Aminoglycoside-Resistant in "MEDICAL»LABORATORY"
What is HLAR?
HLAR stands for High-Level Aminoglycoside-Resistant. This term refers to a strain of bacteria that is resistant to aminoglycoside antibiotics.
How Does HLAR Form?
HLAR forms in bacteria when certain genetic mutations occur. These mutations allow the bacteria to become resistant to aminoglycoside antibiotics, which are normally used to treat bacterial infections.
What Type of Bacteria is HLAR Found In?
HLAR is commonly found in certain species of Gram-negative and Gram-positive bacteria, including Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumanii, are among the most frequent causes of hospital infections.
How Can I Prevent Acquiring an HLAR Infection?
The best way to prevent acquiring an HLAR infection is by practicing good hand hygiene and maintaining proper personal hygiene habits. Additionally, being up to date on vaccinations is also recommended to help lower your risk of contracting an infectious disease.
Are There Treatment Options For An HLAR Infection?
If you think you may have contracted an infection from a strain of bacteria with high-level aminoglycoside resistance, it's important to seek medical attention right away. Your doctor will prescribe the necessary medications based on your individual needs and the severity of your infection.
Can High Level Aminoglycosides be Used To Treat Other Types of Bacterial Infections Besides Those Caused by HLAR?
Yes, high level aminoglycosides can be used to treat some other types of bacterial infections as well. However, it's important for patients and doctors alike to be aware that these medications may not be effective against some strains of bacteria with high level aminoglycoside resistance.
Do All Antibiotics Work Against Bacteria With High Level Aminoglycoside Resistance?
No, not all antibiotics are effective against bacteria with high level aminoglycoside resistance. It's important for patients and doctors alike to discuss potential treatment options in order to ensure that the most appropriate medication or course of treatment is chosen.
Is An HLAR Infection Contagious?
An HLAR infection itself may not be contagious but the underlying bacterial infection caused by the strain with high-level aminoglycoside resistance could potentially spread from one person or animal to another via contact or exposure through contaminated objects such as food or surfaces.
Final Words:
In conclusion, HLAR is an important clinical problem due to its ability to render aminoglycoside antibiotics ineffective against some bacterial infections, leading to treatment failure and increased morbidity/mortality rates among affected individuals. It is essential that healthcare professionals remain vigilant when it comes to identifying and treating antibiotic resistant organisms in order to minimize its effects on patient care outcomes.
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