What does ADC mean in CLINICAL MEDICINE
Antibody–drug conjugates (ADC) are an emerging class of drugs for the treatment of cancer and other diseases. ADCs are designed to combine the specificity of monoclonal antibodies with the potency of cytotoxic chemotherapeutic drugs. The main goal is to direct drugs to tumor cells, thereby sparing normal cells from toxic side effects. Therefore, ADCs represent a major advance in the targeted delivery of potent antineoplastic agents.
ADC meaning in Clinical Medicine in Medical
ADC mostly used in an acronym Clinical Medicine in Category Medical that means Antibodyâ€drug conjugates
Shorthand: ADC,
Full Form: Antibodyâ€drug conjugates
For more information of "Antibodyâ€drug conjugates", see the section below.
What's ADC? Antibody-drug conjugates (ADCs) are medical biopharmaceuticals composed of a monoclonal antibody chemically conjugated to a cytotoxic drug payload via a linker molecule. The molecular structure of an ADC comprises three components
an antibody, which serves as the targeting moiety; a linker system, which connects the target-binding moiety with the drug payload; and a therapeutic agent or payload, such as synthetic toxins or radioactive isotopes capable of killing malignant cells. All components are selected based on their physicochemical and pharmacokinetic properties to obtain optimum efficacy and selectivity in action against cancer cells with minimal impairment on healthy tissue.
Essential Questions and Answers on Antibodyâ€drug conjugates in "MEDICAL»CLINICAL"
What is an ADC?
An Antibody-Drug Conjugate (ADC) is a type of targeted therapy combining the specificity of an antibody with the potency of a cytotoxic drug. It is designed to deliver a highly potent and toxic chemotherapy agent directly and selectively to tumor cells, thus maximizing efficacy while minimizing systemic toxicity.
How are ADCs produced?
ADCs are produced by linking an antibody and a cytotoxic drug through a chemical linker. The linker must be stable in circulation allowing the loaded drug to remain attached to the antibody but dissociate from it at the target site in order for it to elicit its effect.
What are some benefits of using ADCs?
Using an ADC has multiple advantages over traditional chemotherapy drugs, such as improved efficacy, lower toxicity profile, extended duration of action, reduced off-target effects, and increased selectivity for cancer cells.
What types of diseases can be treated with ADCs?
ADCs have been approved for use in treating several types of cancer such as breast cancer, lymphoma, ovarian cancer, as well as some other diseases such as macular degeneration.
How do ADCs work?
When an ADC enters the body, it binds to specific proteins on tumor cells via its monoclonal antibody component. This process targets only cancer cells and avoids normal healthy tissue. Once bound to its target cell surface protein, the payload within the ADC is released into the cell causing cell death or inhibiting growth.
Final Words:
In conclusion, Antibody-Drug Conjugates (ADCs) represent an important new strategy for treating diseases such as cancer where specific targets can be identified on tumor cells without harming healthy tissue. These specialized treatments offer increased potency and improved selectivity compared to traditional chemotherapy drugs while still maintaining low toxicity levels. With further development and refinement, ADCs will continue to play an increasingly vital role in personalized medicine for treating various forms of cancer and other diseases with less harmful side effects than available treatments today.
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