What does CESD mean in MEDICAL

Common symptoms of CESD include abdominal pain, jaundice, fatigue, stunted growth, and dark red urine or grayish stools caused by accumulation of sterol byproducts. It may also be associated with diabetes mellitus type 2 and increased risk for cardiovascular disease.

CESD is caused by mutations in particular genes that cause a deficiency or absence of lysosomal acid lipase (LAL), which breaks down cholesteryl esters into their component parts for disposal or use by the body. Mutations causing this enzyme deficiency result in abnormal accumulation of cholesterol-like molecules in cells throughout the body.

People who have a family history of CESD are at higher risk of developing this condition. While it can affect both males and females, males are more likely to develop severe versions of this condition due to differences in sex-linked gene expression.

Treatment for cholesteryl ester storage disease typically involves lifestyle changes that reduce total cholesterol content as well as medications to allow partial break down and clearance of these cholesteryl esters from tissues; if left untreated, severe consequences may occur such as cirrhosis or even hepatic failure leading to death.

Currently there is no known way to prevent getting Cholesteryl Ester Storage Disease because it is an inherited disorder; however, living a healthy lifestyle with regular exercise and a balanced diet may help reduce some symptoms associated with this condition.