What does ATTR mean in MEDICAL
ATTR is an abbreviation for amyloidogenic transthyretin. Amyloidogenic refers to the ability of a protein to form amyloid fibrils, which are insoluble protein aggregates that can accumulate in tissues and organs, leading to dysfunction and disease. Transthyretin is a protein that is normally produced by the liver and transports thyroid hormones and retinol-binding protein in the blood. Mutations in the transthyretin gene can lead to the production of amyloidogenic transthyretin, which can cause a variety of health problems, including:
ATTR meaning in Medical in Medical
ATTR mostly used in an acronym Medical in Category Medical that means amyloidogenic transthyretin
Shorthand: ATTR,
Full Form: amyloidogenic transthyretin
For more information of "amyloidogenic transthyretin", see the section below.
- ATTR amyloidosis: A condition in which amyloid fibrils accumulate in various organs and tissues, such as the heart, kidneys, nerves, and gastrointestinal tract.
- Familial amyloid polyneuropathy (FAP): A type of ATTR amyloidosis that primarily affects the nerves, causing progressive weakness, numbness, and pain in the hands and feet.
- ATTR cardiomyopathy: A type of ATTR amyloidosis that primarily affects the heart, causing thickening of the heart muscle, heart failure, and arrhythmias.
Meaning of ATTR in MEDICAL
ATTR is a term used in the medical field to describe a specific type of protein that is found in the blood. This protein, called transthyretin, is responsible for transporting thyroid hormones and vitamin A throughout the body. When the transthyretin protein becomes abnormal, it can lead to the development of a condition called ATTR amyloidosis. This condition is characterized by the deposition of amyloid fibrils in various organs and tissues, which can lead to organ damage and dysfunction.
Full Form of ATTR
ATTR stands for amyloidogenic transthyretin. As mentioned earlier, transthyretin is a protein that is produced by the liver and is responsible for transporting thyroid hormones and vitamin A in the blood. However, mutations in the transthyretin gene can lead to the production of amyloidogenic transthyretin, which is a form of transthyretin that is prone to forming amyloid fibrils.
Essential Questions and Answers on amyloidogenic transthyretin in "MEDICAL»MEDICAL"
What is amyloidogenic transthyretin (ATTR)?
ATTR is a rare genetic disease caused by mutations in the transthyretin (TTR) gene. TTR is a protein that helps transport vitamin A in the body. In people with ATTR, mutant TTR proteins misfold and clump together, forming amyloid deposits in various organs and tissues, leading to progressive organ damage.
What are the symptoms of ATTR?
Symptoms of ATTR can vary depending on the organs affected. Common symptoms include progressive weakness, muscle atrophy, numbness or tingling in the hands and feet (peripheral neuropathy), and heart problems such as heart failure or arrhythmias. Other symptoms may include gastrointestinal problems, vision changes, and kidney dysfunction.
How is ATTR diagnosed?
ATTR is diagnosed through a combination of medical history, physical examination, blood tests, and genetic testing. Blood tests can detect elevated levels of TTR fragments, while genetic testing can identify specific mutations in the TTR gene. Tissue biopsy may also be performed to confirm the presence of amyloid deposits.
What are the treatment options for ATTR?
Treatment options for ATTR aim to slow the progression of the disease and alleviate symptoms. These may include:
- Medications: Medications such as tafamidis and inotersen can stabilize the mutant TTR protein and prevent amyloid formation.
- Liver transplant: In severe cases, a liver transplant can be considered to remove the primary source of mutant TTR production.
- Palliative care: Palliative care focuses on managing symptoms and improving quality of life. This may include physical therapy, assistive devices, and pain management.
Is ATTR a fatal disease?
ATTR is a progressive disease that can lead to significant organ damage and eventually death. However, with early diagnosis and appropriate treatment, the progression of the disease can be slowed, and the quality of life can be improved.
Final Words: ATTR is an important term in the medical field that refers to a specific type of protein and a condition associated with its abnormal form. Understanding the meaning of ATTR and its implications can help healthcare professionals provide appropriate diagnosis, treatment, and support to individuals affected by ATTR amyloidosis.