What does SFK mean in UNCLASSIFIED

Src Family Kinases (SFKs) are a group of non-receptor tyrosine kinases that play crucial roles in cellular signaling pathways. They are involved in regulating various cellular processes, including cell growth, differentiation, migration, and adhesion.

SFKs are often overexpressed or hyperactivated in cancer cells, where they contribute to tumorigenesis and cancer progression. They can promote tumor cell proliferation, survival, invasion, and angiogenesis. Targeting SFKs has therefore become a promising therapeutic strategy for treating cancer.

SFKs are regulated by a complex network of mechanisms, including phosphorylation, ubiquitination, and protein-protein interactions. Their activity is tightly controlled to ensure proper cellular function. Dysregulation of SFK regulation can lead to pathological conditions, including cancer.

Targeting SFKs has shown promise in the treatment of various cancers, such as breast cancer, lung cancer, and leukemia. Several SFK inhibitors have been developed and are currently being evaluated in clinical trials. These inhibitors aim to block SFK activity and inhibit tumor growth and progression.

Targeting SFKs can be challenging due to their complex regulatory mechanisms and the potential for off-target effects. Developing selective and potent SFK inhibitors with minimal toxicity remains an active area of research.