What does FDRC mean in HUMAN GENOME
FDRCs are highly branched cells with long processes that form a network-like structure. They express various surface molecules that allow them to interact with B cells and other immune cells. The primary function of FDRCs is to capture and retain immune complexes, which are formed when antibodies bind to antigens. These immune complexes are then presented to B cells, which can recognize and bind to the specific antigen that is bound to the FDRC.
FDRC meaning in Human Genome in Medical
FDRC mostly used in an acronym Human Genome in Category Medical that means Follicular Dendritic Reticulum Cell
Shorthand: FDRC,
Full Form: Follicular Dendritic Reticulum Cell
For more information of "Follicular Dendritic Reticulum Cell", see the section below.
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Function of FDRCs
Role in Antibody Production
The interaction between FDRCs and B cells is essential for the production of antibodies. B cells that bind to antigen-presenting FDRCs undergo clonal expansion and differentiation into antibody-producing plasma cells. FDRCs also provide survival signals to B cells, helping them to maintain their viability and continue producing antibodies.
Clinical Significance
FDRCs play a role in the development of certain autoimmune diseases, such as systemic lupus erythematosus (SLE). In SLE, FDRCs are abnormally activated and produce high levels of chemokines, which attract inflammatory cells to the germinal centers. This inflammation can lead to tissue damage and the production of autoantibodies, which can attack the body's own tissues.
Essential Questions and Answers on Follicular Dendritic Reticulum Cell in "MEDICAL»GENOME"
What is Follicular Dendritic Reticular Cell (FDRC)?
Follicular dendritic reticular cell (FDRC) is a specialized type of stromal cell found in the germinal centers of lymphoid follicles within secondary lymphoid organs such as lymph nodes and the spleen. FDRCs are responsible for presenting antigen to B cells and supporting the development of antibodies.
What is the role of FDRCs in the immune system?
FDRCs play a crucial role in the generation of humoral immune responses. They capture and retain immune complexes, which consist of antigen bound to antibodies. By presenting these immune complexes to B cells, FDRCs facilitate the selection and activation of B cells with high affinity for the antigen. This process leads to the production of antibodies that specifically target the antigen.
How do FDRCs interact with B cells?
FDRCs interact with B cells through a variety of mechanisms. They express surface receptors, such as CD21 and CD35, that bind to complement components and Fc receptors on B cells. These interactions allow FDRCs to capture and retain immune complexes and present them to B cells. Additionally, FDRCs secrete cytokines that promote B cell survival, proliferation, and differentiation into antibody-producing plasma cells.
What happens when FDRCs are dysfunctional?
Dysfunctional FDRCs can impair humoral immune responses. For example, in autoimmune diseases such as lupus, FDRCs may exhibit reduced ability to capture and retain immune complexes. This can lead to impaired B cell activation and antibody production, resulting in a weakened immune response and the development of autoantibodies.
Can FDRCs be targeted for therapeutic purposes?
Yes, FDRCs are a potential target for therapeutic interventions. By modulating FDRC function, it may be possible to enhance or suppress humoral immune responses. For example, targeting FDRCs could be a strategy for treating autoimmune diseases by reducing antibody production or for enhancing vaccine efficacy by promoting B cell activation.
Final Words: FDRCs are crucial cells in the immune system, playing a vital role in antibody production and the development of humoral immunity. Their unique ability to capture and present antigens to B cells makes them essential for the recognition and clearance of pathogens. Understanding the function of FDRCs is important for research into immune-mediated diseases and the development of new therapies.