What does CATS mean in LABORATORY
CATS stands for the Canadian American Ticlopidine Study. It was a clinical trial that was conducted to evaluate the efficacy and safety of ticlopidine hydrochloride (Ticlid) as an antiplatelet agent following coronary artery stenting or balloon angioplasty. The study took place between 1997 and 1999 and involved 930 patients from Canada and the United States. The primary outcome measure of the trial was death, myocardial infarction, or stroke at a 12-month follow-up.
CATS meaning in Laboratory in Medical
CATS mostly used in an acronym Laboratory in Category Medical that means Canadian American Ticlopidine Study
Shorthand: CATS,
Full Form: Canadian American Ticlopidine Study
For more information of "Canadian American Ticlopidine Study", see the section below.
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Background
The CATS trial was designed to determine whether treating patients with Ticlid after undergoing a coronary intervention would reduce their risk of serious cardiovascular events like death, myocardial infarction (heart attack), or stroke more than aspirin alone. Ticlid is known to inhibit platelet aggregation, thereby reducing the risk of clogged arteries due to clotting of blood cells. Aspirin has been shown to have similar anti-clotting effects but without the potential adverse effects associated with strong platelet inhibitors like Ticlid. The study compared the combination of 25 mgs twice daily of Ticlid plus 325 mgs daily of aspirin with 325 mgs daily aspirin alone in 930 patients who had recently undergone a coronary intervention.
Protocol
The 930 patients enrolled in the CATS trial were followed for one year after their initial treatment with either aspirin plus ticlopidine hydrochloride (Ticlid) or aspirin alone. During this time period, they were periodically monitored for any signs of cardiac events such as death, myocardial infarction, or stroke. Additionally, blood tests were taken every three months to evaluate levels of platelet inhibition mediated by ticlopidine hydrochloride. Adverse events related to Ticlid usage also were monitored closely throughout the study's duration.
Results
At the end of 12 months, researchers found that there was no significant difference in outcomes between those taking both drugs vs those taking only one drug (aspirin). In other words, adding ticlopidine did not appear to reduce cardiac events compared to using only aspirin without experiencing any additional adverse side effects commonly seen when using ticlopidine on its own. This finding suggests that there may be no additional benefit provided by adding additional platelet inhibition medications after a coronary artery procedure beyond what is already offered by low-dose aspirin.
Essential Questions and Answers on Canadian American Ticlopidine Study in "MEDICAL»LABORATORY"
What is the purpose of the Canadian American Ticlopidine Study (CATS)?
The CATS is a clinical trial designed to assess the safety and effectiveness of ticlopidine in preventing recurrent stroke in individuals who have recently experienced a stroke or transient ischemic attack.
Who can participate in the CATS?
Patients who have had a clinically confirmed stroke or transient ischemic attack (TIA) within 90 days prior to enrollment in the study, are between 18-80 years old and meet other eligibility criteria may be eligible for participation.
What kind of treatment will participants in the CATS receive?
Participants will be randomized into one of two arms. Arm 1 will be monitored with placebo, while Arm 2 will receive ticlopidine for up to 90 days if they are able to tolerate it.
How long does the CATS last?
Participants will be monitored on an ongoing basis during their time in the trial. Participants may remain in the trial for up to two years after their initial enrollment date.
What information do I need to provide if I am interested in joining the CATS?
Potential participants should provide basic demographic information (name, age, address), medical history, and contact information for their primary care provider or treating neurologist/stroke specialist.
What kind of data will be collected during the course of the study?
The research team collect data regarding participant’s past medical history, current medical health status including lab results and imaging results as well as potential risk factors contributing toward stroke occurrence. Also socio-demographic information such as lifestyle habits and family history may also be included as part of our data collection process throughout trial.
How often should participants take part in follow-up visits?
During follow-up visits participating patients will undergo physical exams, laboratory tests, questionnaires about lifestyles factors, adverse events reporting follow up phone calls every 3 months and a final visit at 2 years from enrollment date if still eligible.
Final Words:
In conclusion, results from the Canadian American Ticlopidine Study suggest that combining ticlopidine hydrochloride with low-dose aspirin following coronary interventions such as angioplasties does not provide any additional benefit over low dose aspirin use alone in reducing serious cardiovascular events such as death, myocardial infarction and stroke within 12 months post procedure.
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