What does MRN mean in UNCLASSIFIED
MRN is an abbreviation used in the field of genetics and medicine. It stands for the MRE11a RAD50 NBN protein complex, which plays a critical role in DNA repair and genome stability.
MRN meaning in Unclassified in Miscellaneous
MRN mostly used in an acronym Unclassified in Category Miscellaneous that means MRE11a RAD50 NBN
Shorthand: MRN,
Full Form: MRE11a RAD50 NBN
For more information of "MRE11a RAD50 NBN", see the section below.
MRN Complex
The MRN complex is composed of three proteins:
- MRE11a (meiotic recombination 11 homolog A): A nuclease that initiates DNA break repair.
- RAD50 (radiation-sensitive 50): A protein that is involved in DNA binding and the recruitment of other repair proteins.
- NBN (nibrin): A protein that is involved in signal transduction and the regulation of DNA repair.
Functions of the MRN Complex
The MRN complex is responsible for the following functions:
- DNA damage signaling: The MRN complex detects and signals DNA damage by phosphorylating other proteins and activating the DNA damage response pathway.
- DNA repair: The MRN complex initiates the repair of DNA double-strand breaks by recruiting and activating other repair proteins.
- Genome stability: The MRN complex is essential for maintaining genome stability by preventing the accumulation of DNA damage and promoting proper DNA repair.
Clinical Significance
Mutations in the genes encoding the MRN complex proteins are associated with several human diseases, including:
- Ataxia-telangiectasia-like disorder (ATLD): A rare inherited disorder characterized by neurological symptoms, immunodeficiency, and an increased risk of cancer.
- Nijmegen breakage syndrome (NBS): A rare inherited disorder characterized by immunodeficiency, growth retardation, and an increased risk of cancer.
Essential Questions and Answers on MRE11a RAD50 NBN in "MISCELLANEOUS»UNFILED"
What is the MRN complex?
The MRN complex is a protein complex involved in DNA damage repair. It is composed of three proteins: MRE11a, RAD50, and NBN. The MRN complex is responsible for sensing and repairing double-strand DNA breaks, which are a common type of DNA damage.
What is the role of MRE11a in the MRN complex?
MRE11a is a DNA endonuclease that is responsible for initiating the repair of double-strand DNA breaks. It also plays a role in the activation of the ATM kinase, which is a key regulator of the DNA damage response.
What is the role of RAD50 in the MRN complex?
RAD50 is a DNA-binding protein that is responsible for tethering the MRN complex to sites of DNA damage. It also plays a role in the activation of the ATM kinase.
What is the role of NBN in the MRN complex?
NBN is a protein that is responsible for bridging the MRN complex to the DNA damage response machinery. It also plays a role in the activation of the ATM kinase.
What are the consequences of mutations in the MRN complex?
Mutations in the MRN complex can lead to a number of disorders, including Nijmegen breakage syndrome and ataxia-telangiectasia. These disorders are characterized by an increased susceptibility to cancer and other genetic instability syndromes.
Final Words: The MRN complex is a vital protein complex that plays a critical role in DNA repair and genome stability. Understanding the function and clinical significance of the MRN complex is important for the diagnosis and treatment of diseases associated with DNA repair defects.
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