What does CATH mean in LABORATORY
CATH, which stands for Class, Architecture, Topology and Homologous, is a classification system specifically designed for the classification of protein structures. CATH assigns proteins into functional categories using an automated process that looks at the shape of the molecule as defined by its three-dimensional structure. CATH is used to describe proteins from organisms ranging from bacteria to humans and is widely used in medical research and biotechnology.
CATH meaning in Laboratory in Medical
CATH mostly used in an acronym Laboratory in Category Medical that means Class, Architecture, Topology, and Homologous
Shorthand: CATH,
Full Form: Class, Architecture, Topology, and Homologous
For more information of "Class, Architecture, Topology, and Homologous", see the section below.
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What does CATH Stand for?
CATH stands for "Class, Architecture, Topology, and Homologous". In other words, it is a classification system designed to classify proteins based on their 3D structure.The four parts of the CATH acronym refer to four aspects of protein structure analysis that help classify proteins into groups. The "Class" part of CATH refers to the most general form of classifying proteins according to their fold classes – alpha/beta proteins, all-alpha proteins or multi-domains complex structures. The "Architecture" part refers to the topological arrangement of secondary structural elements within a fold – helix-turn-helix motifs or mixed up-and-down folds for example. The "Topology" part focuses on local features such as secondary structure loops and turns between two adjacent strands that define a fold's geometry or how it wraps around itself. Finally, the "Homologous" part focusses on the evolutionary relatedness between different families or superfamilies of proteins according to their sequence similarity.Put together, these four components enable an automated process which can categorise a protein's 3D structure into its family group (e.g beta barrel) which may be linked with its biological function (e.g hydrolase).
Application in Medical Science:CATH has many applications in medical science because it enables researchers to predict protein functions by looking at their shapes/structures alone - i.e without having access to any sequence information about them which would be needed in conventional approaches such as BLAST searches or phylogenetic analyses - which makes it useful for investigating viral and bacterial genomes where sequencing data might not be available yet.It also makes important links between disease pathology and specific protein architectures which could open up possibilities in drug design - understanding how certain drugs or molecules interact with certain structures could aid in designing better treatments tailored for specific conditions in humans since different architectures will have different properties that make them more / less susceptible to drug binding etc.. This understanding can also help explain why some diseases will respond better than others depending on what architecture/type they are associated with (these might depend on genetic differences).Overall CATH provides valuable insights into the relationships between molecular structure and biological function that could potentially provide new solutions across swathes of therapeutic areas including cancer research among others.
Essential Questions and Answers on Class, Architecture, Topology, and Homologous in "MEDICAL»LABORATORY"
What is CATH?
CATH stands for Class, Architecture, Topology and Homologous. It is a database containing protein domain classification and structure information about proteins from all species. The database is used to help with automatically predicting the 3D structure of proteins from their amino acid sequence.
How can CATH be useful?
CATH is a valuable resource to researchers as it provides an overview of how different protein domains are related to each other in terms of both their structure and function. This helps scientists better understand the evolutionary history of proteins and helps identify potential therapeutic targets.
What kind of information does CATH provide?
The database contains information on the three-dimensional structures of protein domains as well as their evolutionary relationships. Additionally, it also provides data on the topology (connectivity) between different domains in a single protein, which allows researchers to predict how changes may affect its function.
How does CATH classify proteins?
Proteins are classified according to their phylogenetic relationships in a hierarchical order from general class right down to more specific subclasses and family levels. This helps scientists group together similar structures and generate hypotheses around their shared functionalities.
What type of data does CATH have available?
The database includes information such as amino acid sequences, secondary structural elements, accession numbers and other functional features which are important for understanding the functionality of proteins within organisms. Additionally they contain alignments for comparison purposes and cross-references with other databases such as PDB or UniprotKB/Swissprot.
Who uses CATH?
CATH is primarily used by biologists and biochemists working in drug development, bioinformatics or proteomics research areas who need access to reliable 3D protein structures and comparative analysis tools to aid with their work. However other life scientists may find it useful for gaining insight into proteins from multiple related species at once or studying evolutionary relationships among them.
How often do updates happen in CATH?
Updates are done periodically on an as-needed basis when new or updated data becomes available that requires merging into the existing database structure. All users will be notified when new versions become available for download so they can keep up-to-date with any changes or additions made.
What platforms offer access to CATH?
Various platforms including web interface (CATHDB), command line interface (CLI), Java application (CATHSearch) and Python library (PyCATHSearch) offer access to the database via both public servers hosted by UCL’s Centre for Bioinformatics Resources or via downloading local copies for use either locally or remotely.
Is there any charge associated with using CATH?
No, there is no charge associated with accessing or using any version of CATH – both publically hosted versions online and locally downloaded copies can be used without cost.
Where can I find more information about this service?
More detailed information about using CATHDB, CLI , PyCATHSearch etc can be found on UCL's Centre for Bioinformatics Research website alongside FAQs , tutorials and documentation covering technical aspects such as installation instructions etc.
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