What does TLK mean in UNCLASSIFIED
TLK stands for Tousled Like Kinase. It is a protein kinase that is involved in several cellular processes, including DNA damage response, cell cycle progression, and apoptosis.
TLK meaning in Unclassified in Miscellaneous
TLK mostly used in an acronym Unclassified in Category Miscellaneous that means Tousled Like Kinase
Shorthand: TLK,
Full Form: Tousled Like Kinase
For more information of "Tousled Like Kinase", see the section below.
TLK Structure and Function
TLK is a serine/threonine protein kinase that belongs to the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family. It consists of an N-terminal kinase domain, a central coiled-coil domain, and a C-terminal regulatory domain.
TLK is activated by DNA damage and other cellular stresses. Once activated, it phosphorylates a wide range of substrates, including the tumor suppressor protein p53, the cell cycle regulator cyclin-dependent kinase 2 (CDK2), and the apoptosis regulator Bax.
TLK in DNA Damage Response
TLK plays a critical role in the DNA damage response pathway. It phosphorylates p53, which leads to the activation of p53-dependent transcription and cell cycle arrest. TLK also phosphorylates CDK2, which inhibits cell cycle progression and allows time for DNA repair.
TLK in Cell Cycle Regulation
TLK is involved in cell cycle regulation by phosphorylating CDK2 and other cell cycle regulators. By inhibiting CDK2 activity, TLK prevents the cells from entering mitosis until DNA damage is repaired.
TLK in Apoptosis
TLK can also induce apoptosis, or programmed cell death. It phosphorylates Bax, which triggers the mitochondrial apoptotic pathway.
Essential Questions and Answers on Tousled Like Kinase in "MISCELLANEOUS»UNFILED"
What is Tousled Like Kinase (TLK)?
TLK is a serine/threonine kinase that plays a crucial role in cell cycle regulation, particularly during mitosis. It belongs to the polo-like kinase (PLK) family and is involved in centrosome maturation, spindle assembly, and chromosome segregation.
What are the main functions of TLK?
TLK's primary functions include:
- Phosphorylation of key centrosomal proteins, such as CEP152 and CEP192, which is essential for centrosome maturation and spindle assembly.
- Regulation of mitotic entry through phosphorylation of Aurora A kinase, promoting its activation and centrosome maturation.
- Phosphorylation of Bub1 kinase, influencing spindle assembly checkpoint activation and ensuring proper chromosome segregation.
What are the consequences of TLK dysregulation?
Dysregulation of TLK can lead to various cellular abnormalities, including:
- Mitotic defects, such as abnormal centrosome formation, spindle misalignment, and chromosome missegregation.
- Aberrant cell division and genomic instability, potentially contributing to cancer development.
- Neurodevelopmental disorders, as TLK has been implicated in neuronal migration and differentiation.
How is TLK regulated?
TLK is regulated by multiple mechanisms, including:
- Phosphorylation by various kinases, such as Aurora A and Plk1, modulates its activity and localization.
- Binding to specific proteins, like CEP152 and CEP192, influences its localization and function at the centrosome.
- Ubiquitination and proteasomal degradation contribute to the temporal regulation of TLK activity during mitosis.
What is the significance of TLK in cancer?
TLK overexpression or hyperactivation has been observed in several types of cancer, including breast, lung, and colon cancers. Dysregulated TLK promotes tumor cell proliferation, survival, and genomic instability, contributing to cancer progression. Targeting TLK has shown promise as a therapeutic strategy for cancer treatment.
Final Words: TLK is a protein kinase that is involved in several cellular processes, including DNA damage response, cell cycle progression, and apoptosis. Its activity is regulated by DNA damage and other cellular stresses. Dysregulation of TLK has been implicated in cancer and other diseases.
TLK also stands for: |
|
| All stands for TLK |