What does DLIS mean in UNCLASSIFIED
DLIS stands for Digoxin Like Immunoreactive Substances. It is a term used to describe a group of substances that cross-react with digoxin antibodies in immunoassays, resulting in falsely elevated digoxin concentrations. This can lead to misinterpretation of patient's digoxin levels and inappropriate clinical decision-making.
DLIS meaning in Unclassified in Miscellaneous
DLIS mostly used in an acronym Unclassified in Category Miscellaneous that means Digoxin Like Immunoreactive Substances
Shorthand: DLIS,
Full Form: Digoxin Like Immunoreactive Substances
For more information of "Digoxin Like Immunoreactive Substances", see the section below.
Causes of DLIS
- Endogenous substances:
- Digoxin metabolites (e.g., dihydrodigoxin)
- Cardiac glycosides from plants (e.g., Digitalis purpurea)
- Exogenous substances:
- Antibiotics (e.g., erythromycin, clarithromycin)
- Antiarrhythmics (e.g., amiodarone)
- Immunosuppressants (e.g., cyclosporine)
Impact of DLIS
DLIS can cause:
- Falsely elevated digoxin levels: Leading to unnecessary dose adjustments or even withdrawal of digoxin therapy.
- Misdiagnosis of digoxin toxicity: Resulting in inappropriate treatment and potential harm to the patient.
- Delayed diagnosis of other conditions: Such as heart failure or arrhythmias, which may be masked by falsely elevated digoxin levels.
Management of DLIS
- Clinical assessment: Monitor for signs and symptoms of digoxin toxicity, despite elevated digoxin levels.
- Confirm digoxin levels: Repeat digoxin assays using a different method (e.g., mass spectrometry) to confirm the presence of DLIS.
- Identify the cause: Investigate potential sources of DLIS, such as medications or herbal supplements.
- Adjust treatment: If DLIS is confirmed, adjust digoxin dosage based on clinical assessment and alternative digoxin assays.
Essential Questions and Answers on Digoxin Like Immunoreactive Substances in "MISCELLANEOUS»UNFILED"
What are DLIS (Digoxin Like Immunoreactive Substances)?
DLIS are substances that cross-react with digoxin antibodies in immunoassays, leading to falsely elevated digoxin levels in blood tests. They are not actually digoxin, and their presence can interfere with the accurate measurement of digoxin therapy.
What causes DLIS?
DLIS can be caused by various factors, including:
- Certain medications, such as amiodarone, quinidine, and verapamil
- Herbal supplements, such as St. John's wort and dandelion root
- Endogenous substances, such as digoxin-like compounds produced by the body
- Food, such as liquorice and certain types of tea
How do DLIS affect digoxin levels?
DLIS can interfere with digoxin immunoassays by binding to the same antibodies used to detect digoxin. This leads to an overestimation of digoxin levels, which can result in unnecessary dose adjustments or even toxicity if the true digoxin concentration is not known.
How can I avoid DLIS interference?
To avoid DLIS interference, it is important to:
- Inform your doctor about any medications, supplements, or foods you are taking
- Avoid taking substances known to cause DLIS, if possible
- Consider using alternative methods to measure digoxin levels, such as mass spectrometry
Final Words: DLIS can be a significant problem in immunoassays for digoxin, leading to falsely elevated digoxin levels and potential clinical misinterpretations. It is important for clinicians to be aware of the causes and implications of DLIS, and to carefully assess digoxin levels and consider alternative methods to confirm the presence of true digoxin toxicity. Proper management of DLIS can ensure accurate diagnosis, appropriate treatment, and optimal patient outcomes.
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