What does MECOM mean in NUCLEAR
MECOM, also known as MDS1 and EVI1 complex locus protein EVI1, is a gene that encodes a protein involved in various cellular processes, including transcription regulation, cell cycle progression, and development. Understanding the functions and significance of MECOM is crucial in biomedical research and clinical applications.
MECOM meaning in Nuclear in Academic & Science
MECOM mostly used in an acronym Nuclear in Category Academic & Science that means MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been identified in a plethora of other organisms, and seems to play a relatively conserved developmental role in embryogenesis. EVI1 is a nuclear transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes.
Shorthand: MECOM,
Full Form: MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been identified in a plethora of other organisms, and seems to play a relatively conserved developmental role in embryogenesis. EVI1 is a nuclear transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes.
For more information of "MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been identified in a plethora of other organisms, and seems to play a relatively conserved developmental role in embryogenesis. EVI1 is a nuclear transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes.", see the section below.
Full Form and Meaning
MECOM stands for MDS1 and EVI1 complex locus protein EVI1. It is also known by the following names:
- Ecotropic virus integration site 1 protein homolog (EVI-1)
- Positive regulatory domain zinc finger protein 3 (PRDM3)
Background
MECOM was initially discovered as a common site for retroviral integration in murine myeloid tumors. Subsequent studies revealed its presence in diverse organisms, suggesting its conserved role in development. EVI1, the protein encoded by MECOM, is a nuclear transcription factor that plays a critical role in regulating gene expression.
Functions
MECOM is involved in multiple signaling pathways that control cell cycle progression. It acts as a coactivator and corepressor, influencing the expression of genes involved in DNA replication, cell division, and differentiation. Additionally, EVI1 interacts with other transcription factors and chromatin remodelers to modulate gene expression programs.
Role in Development
MECOM plays a crucial role in embryonic development. It is involved in regulating the formation of specific tissues and organs, including the hematopoietic system, nervous system, and limbs. Mutations in MECOM have been linked to developmental disorders and congenital anomalies.
Clinical Significance
Aberrant expression of MECOM has been implicated in various human diseases, including:
- Myelodysplastic syndromes (MDS): Overexpression of EVI1 is associated with a subtype of MDS characterized by abnormal blood cell production.
- Acute myeloid leukemia (AML): EVI1 overexpression can contribute to the development of AML, a type of blood cancer.
- Solid tumors: EVI1 dysregulation has been observed in several solid tumors, such as breast cancer, lung cancer, and colon cancer.
Essential Questions and Answers on MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. EVI1 was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been identified in a plethora of other organisms, and seems to play a relatively conserved developmental role in embryogenesis. EVI1 is a nuclear transcription factor involved in many signaling pathways for both coexpression and coactivation of cell cycle genes. in "SCIENCE»NUCLEAR"
What is MECOM?
MECOM is a gene that encodes the protein EVI1, also known as MDS1 and EVI1 complex locus protein. It is a transcription factor involved in cell cycle regulation and embryogenesis.
What does EVI1 stand for?
EVI1 has several names: MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein homolog, and positive regulatory domain zinc finger protein 3.
What is the function of EVI1?
EVI1 is a nuclear transcription factor that regulates gene expression and is involved in signaling pathways for cell cycle genes. It plays a role in both coexpression and coactivation of these genes.
Where is EVI1 found?
EVI1 has been identified in various organisms and plays a conserved role in embryogenesis. In humans, it is encoded by the MECOM gene.
What is the significance of EVI1 in cancer?
EVI1 has been associated with certain types of cancer, including myeloid tumors and leukemia. It is often found at the site of retroviral integration in these tumors, suggesting its involvement in cancer development.
Final Words: MECOM is a multifaceted gene that plays a crucial role in cell cycle regulation and development. Its involvement in human diseases highlights its potential as a therapeutic target. Further research is needed to fully understand the mechanisms of action and clinical applications of MECOM.