What does TOAT mean in UNCLASSIFIED
TOAT stands for The Open Artery Trial. It is a clinical trial that is investigating whether a new surgical technique called open artery surgery is better than the current standard of care for treating patients with peripheral artery disease (PAD).
TOAT meaning in Unclassified in Miscellaneous
TOAT mostly used in an acronym Unclassified in Category Miscellaneous that means The Open Artery Trial
Shorthand: TOAT,
Full Form: The Open Artery Trial
For more information of "The Open Artery Trial", see the section below.
What is Peripheral Artery Disease (PAD)?
PAD is a condition in which the arteries in the legs become narrowed or blocked, which reduces blood flow to the legs. This can cause pain, cramping, and numbness in the legs, and can eventually lead to amputation.
What is Open Artery Surgery?
Open artery surgery is a surgical technique that involves opening up the blocked artery and placing a stent to keep it open. This is different from the current standard of care, which involves using a balloon to open up the artery and then placing a stent.
The Open Artery Trial
The Open Artery Trial is a randomized clinical trial that is comparing open artery surgery to the current standard of care for treating PAD. The trial is being conducted at multiple sites in the United States, and is expected to enroll over 1,000 patients.
The primary endpoint of the trial is to compare the rate of major adverse events (MAE) in patients who undergo open artery surgery to the rate of MAE in patients who undergo the current standard of care. MAE is a composite endpoint that includes death, amputation, and myocardial infarction.
Essential Questions and Answers on The Open Artery Trial in "MISCELLANEOUS»UNFILED"
What is The Open Artery Trial (TOAT)?
TOAT is a groundbreaking clinical trial that tests whether opening blocked arteries in patients with critical limb ischemia (CLI) can improve their outcomes and prevent amputation. CLI is a serious condition characterized by a severe lack of blood flow to the legs or feet, which can lead to debilitating pain, ulcers, and tissue death.
Who is eligible for the TOAT trial?
Patients with CLI who have a blocked artery below the knee and are at risk of amputation are potentially eligible for the TOAT trial. The trial is currently enrolling participants at multiple centers in the United States.
What does the TOAT trial involve?
Participants in the TOAT trial are randomly assigned to either receive standard medical therapy or standard therapy plus an endovascular intervention, which is a minimally invasive procedure that opens blocked arteries. The endovascular intervention may involve angioplasty, stenting, or a combination of both.
What are the goals of the TOAT trial?
The primary goal of the TOAT trial is to determine whether opening blocked arteries in patients with CLI can reduce the risk of major amputation. Other goals include assessing the safety and effectiveness of endovascular interventions in this patient population.
What are the potential benefits of participating in the TOAT trial?
Potential benefits of participating in the TOAT trial include improved blood flow to the legs or feet, reduced pain, prevention of amputation, and enhanced quality of life.
What are the potential risks of participating in the TOAT trial?
Potential risks associated with the TOAT trial include bleeding, infection, and complications related to the endovascular intervention. However, these risks are generally low and are carefully monitored by the study team.
How can I find out more about the TOAT trial?
For more information about the TOAT trial, including eligibility criteria and trial sites, please visit the trial website or contact your doctor.
Final Words: The Open Artery Trial is an important clinical trial that is investigating a new surgical technique for treating PAD. The results of the trial will help to determine whether open artery surgery is a better option than the current standard of care.