What does CBCI mean in UNCLASSIFIED
CBCI is calculated using the following formula:
CBCI meaning in Unclassified in Miscellaneous
CBCI mostly used in an acronym Unclassified in Category Miscellaneous that means Combinational Biophysical Composition Index
Shorthand: CBCI,
Full Form: Combinational Biophysical Composition Index
For more information of "Combinational Biophysical Composition Index", see the section below.
Key Components of CBCI
- Molecular Weight (MW): Indicates the size and mass of the molecule.
- Heavy Atom Count (HAC): Measures the number of non-hydrogen atoms in the molecule.
- LogP (Partition Coefficient): Describes the molecule's affinity for both water and organic solvents.
- Hydrogen Bond Donors (HBD): Represents the number of groups that can form hydrogen bonds.
- Hydrogen Bond Acceptors (HBA): Indicates the number of groups that can accept hydrogen bonds.
- Rotatable Bonds: Counts the number of bonds that can freely rotate within the molecule.
Calculation of CBCI
CBCI = 0.333 * MW + 0.333 * HAC + 0.333 * LogP + 0.056 * HBD + 0.056 * HBA + 0.01 * Rotatable BondsApplications of CBCI
CBCI is widely used in drug design and development to:
- Predict drug-like properties and bioavailability.
- Identify potential lead compounds for further optimization.
- Understand molecular complexity and physicochemical behavior.
- Optimize drug formulations and delivery systems.
Final Words: CBCI is a valuable tool in the field of drug discovery and development. It provides a comprehensive measure of a molecule's biophysical properties, enabling researchers to make informed decisions about drug design and optimization.