What does ERAD mean in UNCLASSIFIED


ERAD (Endoplasmic Reticulum Associated Degradation) is a cellular process responsible for identifying and eliminating misfolded or damaged proteins from the endoplasmic reticulum (ER), the organelle responsible for protein synthesis and folding.

ERAD

ERAD meaning in Unclassified in Miscellaneous

ERAD mostly used in an acronym Unclassified in Category Miscellaneous that means Endoplasmic Reticulum Associated Degradation

Shorthand: ERAD,
Full Form: Endoplasmic Reticulum Associated Degradation

For more information of "Endoplasmic Reticulum Associated Degradation", see the section below.

» Miscellaneous » Unclassified

ERAD Process

  1. Detection: Misfolded or damaged proteins are detected by chaperone proteins in the ER, such as BiP and calnexin.
  2. Ubiquitination: The detected proteins are tagged with multiple ubiquitin molecules, a signal for degradation.
  3. Retrotranslocation: Ubiquitinated proteins are retrotranslocated from the ER lumen back into the cytosol.
  4. Proteasomal Degradation: The ubiquitinated proteins are recognized by the proteasome, a cellular machinery that degrades them.
  5. Dislocation: Dislocation channels, such as the Sec61 channel, facilitate the retrotranslocation of proteins from the ER.
  6. Cytosolic Components: The cytosolic proteins Cdc48, p97, and Bag6 play roles in the extraction of misfolded proteins from the ER membrane.

Regulation

ERAD is tightly regulated to ensure the timely and specific removal of misfolded proteins. ER stress, caused by an accumulation of misfolded proteins, activates ERAD to reduce the burden on the ER.

Significance

ERAD plays a crucial role in maintaining cellular homeostasis by eliminating misfolded proteins that could otherwise accumulate and lead to cellular dysfunction. It contributes to:

  • Protein Quality Control: ERAD ensures the production of properly folded proteins, preventing the aggregation and accumulation of defective proteins.
  • Cellular Health: By removing misfolded proteins, ERAD protects cells from toxicity and promotes cellular survival.
  • Disease Prevention: Defects in ERAD have been linked to various diseases, including cystic fibrosis, neurodegenerative disorders, and cancer.

Essential Questions and Answers on Endoplasmic Reticulum Associated Degradation in "MISCELLANEOUS»UNFILED"

What is ERAD?

Endoplasmic Reticulum Associated Degradation (ERAD) is a cellular process that targets misfolded or unassembled proteins for degradation. It occurs within the endoplasmic reticulum (ER), where proteins undergo folding and assembly. Misfolded proteins that fail to achieve their proper conformation or assemble correctly are recognized by ERAD and subsequently degraded.

How does ERAD work?

ERAD involves a series of steps that lead to the ubiquitination of misfolded proteins and their degradation by the proteasome. Initially, misfolded proteins are recognized by ER-resident chaperones, which attempt to assist in their folding and assembly. If folding cannot be corrected, the proteins are targeted for degradation by the binding of ERAD lectins, such as calnexin and calreticulin. These lectins interact with specific glycoproteins and assist in the recruitment of ubiquitin ligases, which attach ubiquitin chains to the misfolded protein. Ubiquitinated proteins are then recognized by the proteasome, which degrades them into small peptides.

What is the role of ERAD in maintaining cellular homeostasis?

ERAD plays a crucial role in maintaining cellular homeostasis by eliminating misfolded proteins that could otherwise accumulate and disrupt cellular function. These misfolded proteins can lead to cellular stress, aggregation, and toxicity. By targeting them for degradation, ERAD helps ensure that only properly folded and functional proteins are retained within the cells.

What are the consequences of impaired ERAD?

Impaired ERAD can lead to the accumulation of misfolded proteins within the ER, resulting in cellular stress and dysfunction. This can contribute to various diseases, including neurodegenerative disorders, metabolic diseases, and immune system disorders.

Are there any therapeutic strategies targeting ERAD?

Recent research has focused on developing therapeutic strategies that target ERAD to modulate protein degradation and alleviate disease conditions. These strategies aim to enhance ERAD function to eliminate misfolded proteins and prevent their accumulation.

Final Words: ERAD is a critical cellular process that identifies and removes misfolded proteins from the endoplasmic reticulum. Its regulation and efficiency are essential for maintaining cellular homeostasis and preventing the accumulation of defective proteins that can lead to disease. Understanding the molecular mechanisms of ERAD offers potential therapeutic targets for various human diseases.

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