What does CZN mean in UNCLASSIFIED
CZN stands for Centrilobular Zonal Necrosis, a condition characterized by the death of liver cells (hepatocytes) in the middle (centrilobular) zone of the liver lobule. It is often associated with certain medications, toxins, and viral infections.
CZN meaning in Unclassified in Miscellaneous
CZN mostly used in an acronym Unclassified in Category Miscellaneous that means Centrilobular Zonal Necrosis
Shorthand: CZN,
Full Form: Centrilobular Zonal Necrosis
For more information of "Centrilobular Zonal Necrosis", see the section below.
Causes
CZN can be caused by various factors, including:
- Medications: Certain medications, such as isoniazid, halothane, and methotrexate, can cause CZN as a side effect.
- Toxins: Exposure to toxins like carbon tetrachloride and ethanol can also lead to CZN.
- Viral infections: Hepatitis viruses, particularly hepatitis B and C, can cause CZN as part of the liver damage they produce.
Pathophysiology
In CZN, the centrilobular zone of the liver lobule is most vulnerable to damage due to reduced oxygen supply and increased metabolic activity. This leads to the death of hepatocytes in this area, creating areas of necrosis.
Clinical Features
CZN typically does not cause any specific symptoms on its own. However, it can contribute to the overall liver damage and dysfunction, leading to:
- Fatigue
- Jaundice (yellowing of the skin and eyes)
- Nausea
- Vomiting
- Abdominal pain
Diagnosis
CZN is diagnosed through a liver biopsy, which involves taking a small sample of liver tissue for microscopic examination. The biopsy can show the characteristic pattern of centrilobular necrosis.
Treatment
The treatment for CZN focuses on addressing the underlying cause. For medication-induced CZN, discontinuing the offending medication is crucial. In cases of toxin exposure, supportive care to remove the toxin from the body may be necessary. For viral hepatitis, antiviral medications may be prescribed.
Essential Questions and Answers on Centrilobular Zonal Necrosis in "MISCELLANEOUS»UNFILED"
What is Centrilobular Zonal Necrosis (CZN)?
Centrilobular Zonal Necrosis (CZN) is a liver disease characterized by the death of liver cells in the centrilobular zone, which is the central region of the liver lobule. CZN is often caused by toxins, such as alcohol, or by certain medications.
What are the symptoms of CZN?
The symptoms of CZN can vary depending on the severity of the disease. Mild cases may not cause any symptoms, while more severe cases can lead to jaundice, abdominal pain, nausea, vomiting, and fatigue. In severe cases, CZN can lead to liver failure and death.
What causes CZN?
CZN is most commonly caused by toxins, such as alcohol. Alcohol can damage the liver cells and lead to their death. Other causes of CZN include certain medications, such as acetaminophen and isoniazid, and certain medical conditions, such as hepatitis and cirrhosis.
How is CZN diagnosed?
CZN is diagnosed based on a combination of blood tests, imaging tests, and a liver biopsy. Blood tests can show elevated levels of liver enzymes, which are released into the bloodstream when liver cells are damaged. Imaging tests, such as an ultrasound or a CT scan, can show changes in the liver's appearance that are consistent with CZN. A liver biopsy is a procedure in which a small sample of liver tissue is removed and examined under a microscope. A liver biopsy can confirm the diagnosis of CZN and rule out other liver diseases.
How is CZN treated?
The treatment for CZN depends on the cause of the disease. If CZN is caused by alcohol, the treatment will involve abstaining from alcohol. If CZN is caused by a medication, the treatment will involve stopping the medication. In some cases, CZN may require treatment with medications to protect the liver from further damage.
Final Words: CZN is a serious liver condition caused by the death of hepatocytes in the centrilobular zone. It can be triggered by various factors, including medications, toxins, and viral infections. Early diagnosis and treatment are essential to prevent further liver damage and complications.
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