What does ACDC mean in BRITISH MEDICINE
ACDC stands for Adiponectin, C1q and Collagen Domain Containing. It refers to a group of proteins involved in various biological processes such as growth and development, gene regulation, cell cycle control, inflammation and energy homeostasis. It is mainly expressed in the liver and other peripheral tissues, and its expression has been demonstrated to be associated with type 2 diabetes mellitus and metabolic syndrome. ACDC proteins are involved in various important physiological functions, including signal transduction pathways that regulate metabolism, immunity and homeostasis.
ACDC meaning in British Medicine in Medical
ACDC mostly used in an acronym British Medicine in Category Medical that means Molecular biology Adiponectin, C1q and collagen domain containing.
Shorthand: ACDC,
Full Form: Molecular biology Adiponectin, C1q and collagen domain containing.
For more information of "Molecular biology Adiponectin, C1q and collagen domain containing.", see the section below.
Functional Characterization
The structural basis of ACDC proteins is composed of an N-terminal cysteine-rich domain (CRD) with immunoglobulin-like folds, followed by a C1q domain containing six conserved cysteines (Cys_1 to Cys_6), which provides the protein's ability to bind covalently to collagen molecules. The C1q domain is further linked by a linker region composed of alpha helical segments to the collagen binding domain (CBD). In addition, many ACDC proteins possess an intracellular proline-rich region (PRR). This PRR is responsible for facilitating the binding of intracellular signaling effectors like SH3 domains found in certain kinases. Furthermore, some ACDCs contain a short carboxyl terminal end that may be involved in posttranslational modification or sorting within cells.
Role In Metabolism
ACDCs participate in a range of metabolic processes that regulate metabolism on both systemic and cellular levels. For instance, adiponectin receptors have been demonstrated to induce glucose uptake by skeletal muscle cells through its action on AMPK activation pathways promoting fatty acid oxidation rather than glycolysis. Additionally, adiponectin can also induce insulin secretion from pancreatic beta cells while suppressing gluconeogenesis from the liver allowing for systemic glucose homeostasis maintenance. Moreover, reduced adiponectin expression has been observed during obesity leading to reduced glucose tolerance as well as impaired hepatic lipid metabolism due to decreased interaction between AdipoR1/2 receptors and PPAR transcription factors which regulate fatty acid storage pathways.
Essential Questions and Answers on Molecular biology Adiponectin, C1q and collagen domain containing. in "MEDICAL»BRITMEDICAL"
What is Adiponectin-C1q-Collagen Domain Containing (ACDC)?
Adiponectin-C1q-Collagen Domain Containing (ACDC) is a gene family involved in the regulation of metabolism and inflammation. It was discovered in humans as a 24-membered protein family characterized by the presence of three domains - an adiponectin, C1q and collagen domain. This gene family has been implicated in the development of metabolic diseases such as obesity, diabetes and arteriosclerosis.
What are the functions of ACDC?
The primary functions of ACDC are to regulate metabolism and inflammatory response in humans. Specifically, it is believed to regulate adipose tissue metabolism, hepatic glucose homeostasis, insulin sensitivity, blood pressure regulation and inflammatory responses in tissues including fat, liver, heart and kidney.
What role does ACDC play in relation to obesity?
Research suggests that the ACDC gene family plays an important role in regulating metabolism and inflammation related to obesity. Studies have shown that variation or mutations in this gene have been associated with increased risk for developing obesity, insulin resistance and other metabolic disorders.
How can ACDC be used to diagnose or treat metabolic disorders?
Although the exact mechanism is not yet fully understood, studying variations or mutations within the genes that make up ACDC can help make diagnoses regarding metabolic disorders such as diabetes or obesity. Additionally, medications targeting portions of this protein may also be developed as potential treatments for these conditions in the future.
How does ACDC work at a molecular level?
Understanding how ACDC works at a molecular level is still largely unclear although it involves multiple pathways at once which include general cellular processes like lipid transport across membranes as well as specific pathways such as those involved with glucose homeostasis and oxidative stress response.
How was ACDC first discovered?
In 2003 researchers conducted a comprehensive screening process for novel human proteins which resulted in identifying 24 members of a new gene family that included an adiponectin, C1q and collagen domain - later known as Adiponectin-C1q-Collagen Domain Containing (ACDC).
Are there any linked diseases associated with changes to the structure or functioning of ACDC?
Yes, research has suggested that genetic variations or mutations within this protein can increase susceptibility to certain diseases including type 2 diabetes, hypertension and coronary artery disease. Additionally changes structural changes can lead to protein misfolding conditions like amyloidosis.
Is there any evidence linking altered levels of circulating adiponectin levels with endocrine disorders?
Yes studies have found associations between altered levels of circulating adiponectins – one component making up part of the larger Adiponectin-C1q-Collagen Domain Containing gene family - with various endocrine disorders such as polycystic ovarian syndrome (PCOS), insulin resistance syndrome (IRS)and hypothalamic amenorrhea (HA).
Is there any evidence linking changes within ACDCR2 with cancer progression?
Recent studies suggest that certain genetic variations within one member specifically known as Adiponectin C1q Collagen Domain Receptor 2 (ACDCR2) may be linked to tumor progression by influencing cancer cells proliferation rates when compared against healthy cells without these variants present.
Final Words:
In conclusion ACDC refers to Adiponectin C1q Collagen Domain Containing proteins which are important regulators for controlling aspects related with metabolism such as energy homeostasis, signaling pathways related with inflammation and cell cycle control promoting general growth & development among organisms. All these functions are evaluated through respective receptors intervening either directly or indirectly allowing for proper functioning throughout all systems in an organism controlled by these types of molecules leading to overall physiological advancement at certain levels .
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