What does CHO mean in UNCLASSIFIED
Chinese Hamster Ovary (CHO) is an immortalized cell line derived from the ovaries of Chinese hamsters (Cricetulus griseus). CHO cells have been extensively used in biotechnology for over 50 years, particularly in the production of therapeutic proteins and antibodies.
CHO meaning in Unclassified in Miscellaneous
CHO mostly used in an acronym Unclassified in Category Miscellaneous that means Chinese Hampster Ovary
Shorthand: CHO,
Full Form: Chinese Hampster Ovary
For more information of "Chinese Hampster Ovary", see the section below.
What is CHO?
CHO cells are highly adaptable and can grow in suspension or adherent cultures. They have a stable genome, making them suitable for long-term cultivation. CHO cells possess efficient protein synthesis machinery, allowing for high-level expression of recombinant proteins.
Applications of CHO Cells
- Biopharmaceutical production: CHO cells are the primary host cells for the commercial production of monoclonal antibodies, therapeutic proteins, and vaccines.
- Biotechnology research: CHO cells provide a valuable platform for studying protein expression, cell biology, and metabolic pathways.
- Drug discovery and screening: CHO cells are used in high-throughput assays to identify and develop new drugs.
Advantages of CHO Cells
- High protein expression: CHO cells have a robust protein synthesis machinery, enabling efficient production of recombinant proteins.
- Genetic stability: The stable genome of CHO cells reduces the risk of genetic drift and ensures consistent protein expression over time.
- Scalability: CHO cells can be easily scaled up in bioreactors to meet large-scale production demands.
- Regulatory compliance: CHO cells have a well-established regulatory history, making them suitable for the production of biologics intended for human use.
Essential Questions and Answers on Chinese Hampster Ovary in "MISCELLANEOUS»UNFILED"
What is Chinese Hamster Ovary (CHO)?
CHO is a cell line derived from the ovary of the Chinese hamster (Cricetulus griseus). CHO cells are widely used in biotechnology for the production of recombinant proteins, monoclonal antibodies, and other biopharmaceuticals.
Why are CHO cells used in biotechnology?
CHO cells are preferred for biotechnology applications due to several advantages:
- Good protein expression: They have a high capacity for protein production and can produce complex proteins efficiently.
- Stabilization: CHO cells can produce proteins with correct folding and post-translational modifications.
- Scalability: CHO cells can be easily scaled up for large-scale production.
- Safety: CHO cells are not pathogenic to humans or animals.
What products are made using CHO cells?
Many important therapeutic and diagnostic products are produced using CHO cells, including:
- Monoclonal antibodies for cancer therapy, autoimmune diseases, and infectious diseases.
- Recombinant proteins for hormones, enzymes, and growth factors.
- Vaccines for viral and bacterial infections.
- Diagnostic reagents for medical tests.
Are CHO-derived products safe for human use?
CHO-derived products have been extensively tested and are generally considered safe for human use. Regulatory agencies such as the FDA and EMA carefully evaluate the safety and efficacy of biopharmaceuticals produced in CHO cells.
What are the limitations of using CHO cells?
While CHO cells are widely used, they have some limitations:
- Immunogenicity: CHO cells contain non-human proteins that can trigger an immune response in patients.
- Glycosylation: The glycosylation pattern of proteins produced in CHO cells may differ from the natural counterpart, which can affect their efficacy and safety.
- Cost: CHO cell culture is relatively expensive, which can impact the cost of biopharmaceutical production.
Final Words: Chinese Hamster Ovary (CHO) cells are an essential tool in biotechnology, providing a reliable and scalable platform for the production of therapeutic proteins and antibodies. Their adaptability, high protein expression, and genetic stability make them a valuable choice for biopharmaceutical production and research.
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