What does AEZ mean in UNCLASSIFIED


AEZ stands for Acrodermatitis Enteropathica Zinc, a rare inherited disease characterized by impaired zinc absorption. It primarily affects infants and young children, leading to a deficiency of zinc in the body.

AEZ

AEZ meaning in Unclassified in Miscellaneous

AEZ mostly used in an acronym Unclassified in Category Miscellaneous that means Acrodermatitis Enteropathica Zinc

Shorthand: AEZ,
Full Form: Acrodermatitis Enteropathica Zinc

For more information of "Acrodermatitis Enteropathica Zinc", see the section below.

» Miscellaneous » Unclassified

Symptoms

Skin: AEZ causes severe skin lesions and inflammation, particularly on the face, extremities, and buttocks. These lesions are characterized by redness, scaling, oozing, and crusting. Gastrointestinal: Patients may experience persistent diarrhea, vomiting, and abdominal pain due to impaired zinc absorption and inflammation in the digestive tract. Hair: Hair loss (alopecia) is common in AEZ, especially in the eyebrows and scalp, due to zinc deficiency's impact on hair growth. Immune: Zinc deficiency weakens the immune system, making patients susceptible to infections and delayed wound healing.

Causes

AEZ is caused by mutations in the SLC39A4 gene, which encodes a protein responsible for zinc uptake in the small intestine. These mutations lead to impaired zinc absorption, resulting in zinc deficiency.

Treatment

The primary treatment for AEZ is oral zinc supplementation to restore normal zinc levels in the body. This supplementation effectively resolves the skin lesions, gastrointestinal symptoms, and immune dysfunction associated with the disease.

Essential Questions and Answers on Acrodermatitis Enteropathica Zinc in "MISCELLANEOUS»UNFILED"

What is Acrodermatitis Enteropathica (AEZ)?

AEZ is a rare genetic disorder that affects the body's ability to absorb zinc from food. It usually develops in early infancy and is characterized by a distinctive skin rash, hair loss, and diarrhea.

What causes AEZ?

AEZ is caused by mutations in the SLC39A4 gene, which encodes a protein that is responsible for transporting zinc into cells. These mutations result in a deficiency of zinc in the body.

What are the symptoms of AEZ?

The classic symptoms of AEZ include:

  • Periorificial and acral dermatitis (skin rash around the mouth and on the hands and feet)
  • Alopecia (hair loss)
  • Diarrhea
  • Failure to thrive
  • Impaired immune function
  • Delayed wound healing

How is AEZ diagnosed?

AEZ is diagnosed based on clinical symptoms, a physical examination, and blood tests that show low zinc levels. A genetic test can also confirm the diagnosis.

How is AEZ treated?

The treatment for AEZ is zinc supplementation. Zinc is typically given orally as a supplement or as part of a fortified formula. In some cases, intravenous zinc may be necessary.

What is the prognosis for people with AEZ?

With prompt diagnosis and treatment, the prognosis for people with AEZ is generally good. Most individuals are able to live normal lives with zinc supplementation. However, if left untreated, AEZ can lead to severe complications, including intellectual disability and death.

Is AEZ inherited?

AEZ is an autosomal recessive disorder, which means that both parents must carry the gene mutation for the child to inherit the condition. Individuals who carry one copy of the gene mutation are called carriers and do not usually show symptoms of AEZ.

Final Words: AEZ is a rare genetic disorder that affects zinc absorption in the body. It primarily affects infants and young children, causing severe skin lesions, gastrointestinal problems, and immune deficiencies. Early diagnosis and treatment with zinc supplementation are crucial for managing the symptoms and preventing long-term complications.

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