What does TEER mean in ELECTRONICS
TEER stands for Trans Endothelial Electrical Resistance. It is a measure of the electrical resistance across a layer of endothelial cells, and is used to assess the tightness of the endothelial cell barrier.
TEER meaning in Electronics in Academic & Science
TEER mostly used in an acronym Electronics in Category Academic & Science that means Trans Endothelial Electrical Resistance
Shorthand: TEER,
Full Form: Trans Endothelial Electrical Resistance
For more information of "Trans Endothelial Electrical Resistance", see the section below.
What is TEER?
TEER is a measure of the resistance to the flow of ions across a layer of endothelial cells. It is measured using a voltmeter and two electrodes, one placed on the luminal side of the endothelial cell layer and the other placed on the abluminal side. The resistance is measured in ohms per square centimeter (Ω/cm2).
Importance of TEER
TEER is an important measure of endothelial cell barrier function. A high TEER indicates that the endothelial cell layer is tight and impermeable to ions, while a low TEER indicates that the endothelial cell layer is leaky.
Factors that affect TEER
TEER is affected by a number of factors, including:
- Cell type
- Cell density
- Culture conditions
- Presence of cytokines and growth factors
Essential Questions and Answers on Trans Endothelial Electrical Resistance in "SCIENCE»ELECTRONICS"
What is Trans Endothelial Electrical Resistance (TEER)?
Trans Endothelial Electrical Resistance (TEER) measures the resistance to electrical current flow across a cell monolayer cultured on a porous membrane. It reflects the tightness of the cell junctions and the integrity of the endothelial barrier. TEER is commonly used to assess the integrity of endothelial cell monolayers in vitro and the barrier function of endothelial cells in vivo.
How is TEER measured?
TEER is measured using a voltmeter and a pair of electrodes placed on either side of the cell monolayer. The electrical resistance is measured in ohms (Ω) and is directly proportional to the tightness of the cell junctions. A higher TEER value indicates a tighter cell monolayer and better barrier function.
What is a normal TEER value?
The normal TEER value for endothelial cell monolayers varies depending on the cell type, culture conditions, and measurement method. However, a TEER value above 1000 Ω cm2 is generally considered to be indicative of a confluent and intact endothelial cell monolayer.
What factors can affect TEER?
Several factors can affect TEER, including:
- Cell type and culture conditions
- Culture duration
- Presence of inflammatory mediators
- Exposure to toxins or drugs
- Mechanical stress
What are the applications of TEER?
TEER has various applications in biomedical research and drug development, including:
- Assessing the integrity of endothelial cell monolayers in vitro
- Studying the barrier function of endothelial cells in vivo
- Evaluating the effects of drugs and toxins on endothelial cell function
- Developing new therapies to improve endothelial barrier function
Final Words: TEER is a valuable tool for assessing the tightness of the endothelial cell barrier. It is used in a variety of research and clinical applications, including:
- Studying the effects of drugs and toxins on endothelial cell function
- Diagnosing and monitoring endothelial cell dysfunction
- Developing new therapies to treat endothelial cell dysfunction