What does ESBAR mean in UNCLASSIFIED
ESBAR stands for Endogenous Sensitizer of Beta Adrenergic Receptors. It is a naturally occurring substance found in the body that plays a crucial role in regulating the activity of beta-adrenergic receptors (β-ARs). These receptors are responsible for mediating the effects of the neurotransmitter norepinephrine (also known as noradrenaline) and the hormone epinephrine (also known as adrenaline).
ESBAR meaning in Unclassified in Miscellaneous
ESBAR mostly used in an acronym Unclassified in Category Miscellaneous that means Endogenous Sensitizer of Beta Adrenergic Receptors
Shorthand: ESBAR,
Full Form: Endogenous Sensitizer of Beta Adrenergic Receptors
For more information of "Endogenous Sensitizer of Beta Adrenergic Receptors", see the section below.
ESBAR's Role
ESBAR acts as a positive allosteric modulator of β-ARs, meaning it increases the sensitivity of these receptors to their ligands (norepinephrine and epinephrine). By doing so, ESBAR enhances the effects of these neurotransmitters and hormones, which can lead to:
- Increased heart rate and contractility
- Bronchial dilation
- Vasodilation
- Increased metabolic rate
- Inhibition of insulin release
ESBAR in Disease
Dysregulation of ESBAR activity has been implicated in various diseases, including:
- Heart failure: Reduced ESBAR levels may contribute to impaired β-AR signaling, leading to decreased cardiac function.
- Asthma: Increased ESBAR activity may enhance β-AR-mediated airway relaxation, providing therapeutic benefits.
- Obesity: ESBAR has been associated with increased metabolic rate and reduced fat accumulation.
ESBAR as a Therapeutic Target
Given its role in regulating β-AR signaling, ESBAR has emerged as a potential therapeutic target for various diseases. Modulating ESBAR activity could provide novel approaches for treating conditions such as heart failure, asthma, and obesity.
Essential Questions and Answers on Endogenous Sensitizer of Beta Adrenergic Receptors in "MISCELLANEOUS»UNFILED"
What is ESBAR?
Endogenous Sensitizer of Beta Adrenergic Receptors (ESBAR) is a protein that enhances the sensitivity of beta-adrenergic receptors (β-ARs) to catecholamines, such as epinephrine and norepinephrine.
Where is ESBAR found?
ESBAR is predominantly expressed in the heart, skeletal muscle, and adipose tissue.
What is the function of ESBAR?
ESBAR modulates the β-AR signaling pathway, influencing cardiac contractility, glucose metabolism, and lipolysis. It enhances the response of β-ARs to catecholamines, leading to increased heart rate, force of contraction, and metabolic activity.
How does ESBAR enhance β-AR sensitivity?
ESBAR interacts with the β2-AR subtype and stabilizes its active conformation, increasing its affinity for catecholamines. This conformational change promotes G protein coupling and downstream signaling events.
What are the implications of ESBAR in cardiovascular disease?
Altered ESBAR expression and function have been linked to various cardiovascular conditions. Reduced ESBAR levels or impaired activity can diminish β-AR responsiveness, leading to impaired cardiac function and metabolic dysregulation.
Is ESBAR a potential therapeutic target for heart failure?
Enhancing ESBAR function or restoring its expression has been proposed as a potential strategy for improving β-AR signaling and cardiac function in heart failure. However, further research is needed to explore the therapeutic potential and safety of targeting ESBAR.
Final Words: ESBAR is an endogenous substance that plays a crucial role in regulating β-adrenergic receptors. Its involvement in various physiological processes and diseases makes it a promising therapeutic target for future medical interventions.