What does GGR mean in HUMAN GENOME
Global Genome Repair (GGR) is a mechanism that cells utilize to mend extensive DNA damage, such as double-strand breaks (DSBs). This complex process involves several pathways, including homologous recombination (HR) and non-homologous end joining (NHEJ).
GGR meaning in Human Genome in Medical
GGR mostly used in an acronym Human Genome in Category Medical that means Global Genome Repair
Shorthand: GGR,
Full Form: Global Genome Repair
For more information of "Global Genome Repair", see the section below.
» Medical » Human Genome
GGR Pathways
1. Homologous Recombination (HR):
- Repairs DSBs using an undamaged DNA template, usually the sister chromatid.
- High-fidelity repair process that maintains genomic integrity.
2. Non-Homologous End Joining (NHEJ):
- Joins broken DNA ends without a template.
- Less precise than HR, but more efficient for repairing certain types of damage.
Regulation and Importance
GGR is tightly regulated to ensure proper DNA repair and prevent genomic instability. Dysregulation of GGR can lead to genetic diseases and cancer.
Essential Questions and Answers on Global Genome Repair in "MEDICAL»GENOME"
What is Global Genome Repair (GGR)?
GGR is a cellular process that repairs DNA damage throughout the entire genome, regardless of its location. It is a major mechanism for maintaining genome stability and preventing mutations.
How does GGR differ from other DNA repair pathways?
Unlike other DNA repair pathways that target specific types of DNA damage or occur in specific regions of the genome, GGR can repair a wide range of DNA lesions and operates throughout the genome.
What mechanisms are involved in GGR?
GGR involves two main mechanisms: homology-directed repair (HDR) and non-homologous end joining (NHEJ). HDR uses a homologous DNA sequence as a template to repair the damaged region, while NHEJ directly joins the broken DNA ends without using a template.
What is the role of GGR in maintaining genome stability?
GGR plays a crucial role in ensuring the integrity of the genome. By repairing DNA damage throughout the genome, it prevents the accumulation of mutations that can lead to genomic instability and diseases such as cancer.
How is GGR regulated?
GGR is tightly regulated by various cellular factors and signaling pathways. These factors include DNA damage sensors, kinases, and chromatin modifiers. The regulation of GGR ensures that it is activated in response to DNA damage and functions efficiently to restore genome integrity.
Final Words: Global Genome Repair is essential for maintaining genome stability and protecting cells from the consequences of DNA damage. Understanding the mechanisms and regulation of GGR is crucial for developing therapies that target DNA repair pathways in disease settings.
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