What does MVP mean in UNCLASSIFIED
MVP (Major Vault Protein) is a large, multi-subunit protein that is involved in a variety of cellular processes, including nuclear transport, RNA processing, and cell signaling. MVP is expressed in a wide range of cell types, and its expression is often increased in cancer cells.
MVP meaning in Unclassified in Miscellaneous
MVP mostly used in an acronym Unclassified in Category Miscellaneous that means Major Vault Protein
Shorthand: MVP,
Full Form: Major Vault Protein
For more information of "Major Vault Protein", see the section below.
Structure and Function
MVP is a large protein complex that is composed of eight different subunits. The subunits are arranged in a barrel-shaped structure, with a central pore that is used for the transport of molecules into and out of the nucleus. MVP is also associated with a number of other proteins, including nucleoporins, RNA-binding proteins, and protein kinases. These proteins help MVP to carry out its various functions.
Role in Nuclear Transport
MVP is a major component of the nuclear pore complex, which is a large protein complex that spans the nuclear envelope. The nuclear pore complex regulates the transport of molecules into and out of the nucleus. MVP is thought to play a role in the transport of proteins, RNA, and other molecules through the nuclear pore complex.
Role in RNA Processing
MVP is also involved in the processing of RNA. MVP binds to RNA molecules and helps to protect them from degradation. MVP also helps to splice RNA molecules, which is a process that is required for the production of mature mRNA.
Role in Cell Signaling
MVP is also involved in cell signaling. MVP binds to a number of different proteins that are involved in cell signaling pathways. These proteins include growth factors, cytokines, and hormones. MVP is thought to help these proteins to activate their downstream signaling pathways.
Essential Questions and Answers on Major Vault Protein in "MISCELLANEOUS»UNFILED"
What is Major Vault Protein (MVP)?
Major Vault Protein (MVP) is a highly conserved protein that is widely expressed in eukaryotic cells. It is the main component of the vault ribonucleoprotein particle (vRNP), a large, multi-subunit complex that is involved in several cellular processes, including nucleocytoplasmic transport, RNA metabolism, and immune responses.
What is the structure of MVP?
MVP is a large protein with a molecular weight of approximately 220 kDa. It consists of an N-terminal Major Vault Protein Homology Domain (MVHD) and a C-terminal Vault Protein Interacting Domain (VPID). The MVHD contains numerous HEAT (Huntingtin, Elongation factor 3, a subunit of PP2A, TOR1) repeats, which form a solenoid-like structure. The VPID is responsible for binding to other vault proteins and for the assembly of the vRNP complex.
What are the functions of MVP?
MVP is involved in a variety of cellular functions, including:
- Nucleocytoplasmic transport: MVP is a component of the nuclear pore complex (NPC), which is responsible for the transport of molecules between the nucleus and the cytoplasm.
- RNA metabolism: MVP is involved in the processing and transport of RNA molecules. It has been shown to bind to RNA polymerase II and to be involved in the splicing and export of mRNA.
- Immune responses: MVP is expressed in immune cells and is involved in the regulation of immune responses. It has been shown to bind to the complement protein C3 and to be involved in the activation of the complement cascade.
What is the clinical significance of MVP?
MVP is overexpressed in a variety of cancers, including breast cancer, lung cancer, and colon cancer. Overexpression of MVP has been associated with increased cell proliferation, invasion, and metastasis. MVP is also a potential target for cancer therapy. Several inhibitors of MVP have been developed, and some have shown promising results in preclinical studies.
Final Words: MVP is a large, multi-subunit protein that is involved in a variety of cellular processes, including nuclear transport, RNA processing, and cell signaling. MVP is expressed in a wide range of cell types, and its expression is often increased in cancer cells. Further research is needed to fully understand the role of MVP in these processes.
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