What does NRRE mean in NUCLEAR
An NRRE is a specific DNA sequence that acts as a binding site for nuclear receptors (NRs) in the nucleus of cells. NRs are a group of intracellular proteins that regulate gene expression by binding to NRREs and controlling the transcription of specific genes.
NRRE meaning in Nuclear in Academic & Science
NRRE mostly used in an acronym Nuclear in Category Academic & Science that means Nuclear Receptor Responsive Element
Shorthand: NRRE,
Full Form: Nuclear Receptor Responsive Element
For more information of "Nuclear Receptor Responsive Element", see the section below.
- NRRE (Nuclear Receptor Responsive Element) is a specific DNA sequence that acts as a binding site for nuclear receptors, a class of proteins that play a crucial role in regulating gene expression.
- NRREs are located in the regulatory regions of genes and are responsible for controlling the transcription of these genes by nuclear receptors.
Function of NRREs
- Nuclear receptors are ligand-activated transcription factors that bind to NRREs upon binding of their specific ligands.
- Ligand binding induces a conformational change in the nuclear receptor, allowing it to interact with co-activators or co-repressors.
- These co-regulators either facilitate or hinder the recruitment of RNA polymerase II to the promoter region of the target gene, thereby regulating gene transcription.
Types of NRREs
- Different nuclear receptors recognize specific NRRE motifs, which vary in their sequence and organization.
- Some common NRREs include:
- ERE (Estrogen Response Element): recognized by estrogen receptors
- ARE (Androgen Response Element): recognized by androgen receptors
- GRE (Glucocorticoid Response Element): recognized by glucocorticoid receptors
- RXRE (Retinoid X Receptor Response Element): recognized by retinoid X receptors
Essential Questions and Answers on Nuclear Receptor Responsive Element in "SCIENCE»NUCLEAR"
What is a Nuclear Receptor Responsive Element (NRRE)?
How does a NRRE work?
When an NR binds to its cognate NRRE, it recruits other proteins to form a transcriptional complex. This complex modifies the chromatin structure around the gene, making it more accessible to RNA polymerase and other transcription factors. As a result, the target gene is either activated or repressed, depending on the specific NR and the context of the NRRE.
What is the significance of NRREs?
NRREs play a crucial role in regulating various biological processes, including metabolism, development, reproduction, and immune function. By controlling the expression of genes, NRs and their cognate NRREs can influence cell growth, differentiation, and survival.
Are there different types of NRREs?
Yes, there are different types of NRREs that can bind to different NRs. Some common NRREs include the estrogen response element (ERE), androgen response element (ARE), glucocorticoid response element (GRE), and thyroid hormone response element (TRE). Each NRRE has a unique sequence that is recognized by its specific NR.
How are NRREs identified?
NRREs can be identified through a combination of experimental and computational approaches. Experimental methods include chromatin immunoprecipitation sequencing (ChIP-seq) and electrophoretic mobility shift assays (EMSAs), which can identify NR binding sites in DNA. Computational methods use sequence analysis algorithms to predict NRREs based on their consensus sequences.
Final Words:
- NRREs are essential cis-regulatory elements that facilitate the binding of nuclear receptors and regulate gene expression in response to specific hormonal or environmental signals.
- They play a pivotal role in various physiological processes, including metabolism, development, and immune responses.
- Understanding the function and mechanisms of NRREs is crucial for gaining insights into the molecular basis of gene regulation and developing targeted therapies for diseases associated with nuclear receptor signaling.