What does PIRC mean in UNCLASSIFIED
PIRC stands for Platelet Indirect Radioactive Coombs. It is a laboratory test used to diagnose immune thrombocytopenia (ITP), a condition in which the immune system mistakenly attacks and destroys platelets, leading to low platelet counts.
PIRC meaning in Unclassified in Miscellaneous
PIRC mostly used in an acronym Unclassified in Category Miscellaneous that means Platelet Indirect Radioactive Coombs
Shorthand: PIRC,
Full Form: Platelet Indirect Radioactive Coombs
For more information of "Platelet Indirect Radioactive Coombs", see the section below.
What is a PIRC Test?
The PIRC test involves incubating the patient's serum with their own platelets. If the patient has antibodies against their platelets, these antibodies will bind to the platelets. Radioactive-labeled anti-human globulin (AHG) is then added, which binds to any antibodies that have attached to the platelets. The radioactivity is measured to determine the amount of antibody binding, indicating the presence of antiplatelet antibodies.
How the PIRC Test is Performed
- A blood sample is collected.
- The platelets are isolated from the blood.
- The platelets are incubated with the patient's serum.
- Radioactive AHG is added.
- The radioactivity is measured.
Interpretation of PIRC Test Results
- Positive result: A high level of radioactivity indicates the presence of antiplatelet antibodies, suggesting ITP.
- Negative result: A low level of radioactivity indicates the absence of antiplatelet antibodies, excluding ITP as the cause of thrombocytopenia.
Advantages of the PIRC Test
- It is a specific and sensitive test for detecting antiplatelet antibodies.
- It can help differentiate between ITP and other causes of thrombocytopenia.
- It can be used to monitor the response to treatment in ITP patients.
Disadvantages of the PIRC Test
- It requires specialized equipment and trained personnel to perform.
- It can be time-consuming and expensive.
- It may not be available in all laboratories.
Essential Questions and Answers on Platelet Indirect Radioactive Coombs in "MISCELLANEOUS»UNFILED"
What is a Platelet Indirect Radioactive Coombs (PIRC)?
A Platelet Indirect Radioactive Coombs (PIRC) test is a laboratory procedure used to detect antibodies that bind to platelets, which are small blood cells involved in clotting.
Why is a PIRC test performed?
A PIRC test is typically performed to investigate unexplained platelet destruction, such as in cases of immune thrombocytopenia (ITP), a condition where the immune system mistakenly attacks and destroys platelets.
How is a PIRC test done?
A PIRC test involves the following steps:
- Collecting a blood sample
- Separating the platelets from the rest of the blood
- Incubating the platelets with a radioactive antibody called Coombs' reagent
- Measuring the amount of radioactivity bound to the platelets
What do the results of a PIRC test mean?
A positive PIRC test indicates the presence of antibodies that bind to platelets, suggesting that an immune reaction is involved in platelet destruction. A negative PIRC test means that no antibodies were detected, indicating that other factors may be responsible for platelet destruction.
Are there any risks associated with a PIRC test?
The PIRC test is generally considered a safe procedure with minimal risks. However, as with any blood test, there is a small risk of discomfort or bruising at the injection site.
Final Words: The PIRC test is a valuable diagnostic tool for immune thrombocytopenia. It can help determine the cause of thrombocytopenia and guide treatment decisions. However, it is important to note that a negative PIRC test does not completely rule out ITP, and further evaluation may be necessary in some cases.
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