What does ADME mean in PHYSIOLOGY
ADME, an acronym in the field of pharmacology and drug development, stands for Absorption, Distribution, Metabolism, and Excretion. These four processes describe the journey of a drug within the body, from its entry into the body to its elimination.
ADME meaning in Physiology in Medical
ADME mostly used in an acronym Physiology in Category Medical that means Absorption, Distribution, Metabolism, and Excretio
Shorthand: ADME,
Full Form: Absorption, Distribution, Metabolism, and Excretio
For more information of "Absorption, Distribution, Metabolism, and Excretio", see the section below.
» Medical » Physiology
Absorption
Absorption refers to the process by which a drug enters the bloodstream. The route of administration, such as oral, intravenous, or topical, influences the absorption rate and mechanism. Factors like pH, solubility, and drug formulation also play a role in absorption.
Distribution
Distribution describes the movement of the drug throughout the body once absorbed into the bloodstream. It involves the transport of the drug to various tissues and organs, where it may bind to receptors or exert its therapeutic effects. Distribution is influenced by factors like blood flow, protein binding, and tissue permeability.
Metabolism
Metabolism refers to the chemical transformation of the drug within the body. This process typically occurs in the liver and involves enzymes that break down the drug into metabolites. Metabolism can alter the drug's potency, half-life, and side effects.
Excretion
Excretion refers to the elimination of the drug or its metabolites from the body. The primary routes of excretion are through the kidneys (urine) and liver (bile), with some drugs also being excreted through sweat, saliva, or feces. The rate of excretion determines the duration of the drug's action in the body.
Essential Questions and Answers on Absorption, Distribution, Metabolism, and Excretio in "MEDICAL»PHYSIOLOGY"
What is ADME?
ADME stands for Absorption, Distribution, Metabolism, and Excretion. It describes the journey of a drug or chemical compound in the body.
Why is ADME important?
ADME studies help predict how a drug will behave in the body, including how much will be absorbed, how it will be distributed to different tissues, how it will be metabolized or broken down, and how it will be excreted from the body. This information is crucial for designing safe and effective drugs.
What is the absorption phase?
Absorption refers to the process by which a drug enters the bloodstream. This can occur through different routes, such as oral ingestion, injection, or skin absorption.
What is the distribution phase?
Distribution describes how a drug is transported and distributed throughout the body. It involves binding to plasma proteins, crossing cell membranes, and reaching target organs.
What is the metabolism phase?
Metabolism involves the chemical transformation of a drug into metabolites, often by enzymes in the liver. Metabolism can activate or inactivate a drug and influence its duration of action.
What is the excretion phase?
Excretion refers to the elimination of a drug and its metabolites from the body. This primarily occurs through the kidneys (urine) or bile (feces).
How does ADME affect drug efficacy and toxicity?
ADME properties influence the amount of drug that reaches its target and the duration of its action. They can also affect the potential for side effects and toxicity by determining how much drug accumulates in the body.
Final Words: Understanding ADME is crucial for drug development and optimization. By studying these processes, scientists and clinicians can design drugs with desirable pharmacokinetic properties, ensuring their effective and safe use in patients.
ADME also stands for: |
|
| All stands for ADME |