What does MAGIC mean in MEDICAL


The Meta-analysis of Glucose and Insulin Related Traits Consortium (MAGIC) is an international consortium of scientists from academia, industry and non-profit organizations working together to identify genetic risk factors for type 2 diabetes and related traits. The group was established in 2006 with the primary objective of using a meta-analysis approach to identify gene variants associated with type 2 diabetes and related traits in a large population sample.

MAGIC

MAGIC meaning in Medical in Medical

MAGIC mostly used in an acronym Medical in Category Medical that means Meta-analysis of Glucose and Insulin Related Traits Consortium

Shorthand: MAGIC,
Full Form: Meta-analysis of Glucose and Insulin Related Traits Consortium

For more information of "Meta-analysis of Glucose and Insulin Related Traits Consortium", see the section below.

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Purpose

The purpose of the MAGIC consortium is to improve our understanding of how genes influence sugar metabolism, glucose levels, and insulin production, all factors that are important in the prevention and management of type 2 diabetes. This knowledge can help inform medical treatments for the disease tailored to an individual's genetics. In addition, MAGIC conducts research to identify novel gene associations with other polygenic diseases like obesity. The findings can also be used by pharmaceutical companies to develop new drugs that target different pathways associated with these conditions.

Methodology

The MAGIC consortium uses a combination of bioinformatics techniques as well as genotyping technology to study genetic data from thousands of individuals across multiple populations worldwide. They use powerful statistical methods such as meta-analyses which combines data from multiple studies, making it possible to detect very small genetic effects that may otherwise be undetected. Additionally, they combine this data with other known biological processes related to glucose metabolism in order to come up with a more comprehensive picture of how genes contribute to diabetes and related traits.

Essential Questions and Answers on Meta-analysis of Glucose and Insulin Related Traits Consortium in "MEDICAL»MEDICAL"

What is the Meta-Analysis of Glucose and Insulin Related Traits Consortium?

The Meta-Analysis of Glucose and Insulin Related Traits Consortium (MAGIC) is an international research collaboration that was established in 2006. It's aim is to identify genetic factors associated with Type 2 diabetes and related metabolic traits by performing large-scale meta-analyses of multiple studies.

What are some of the objectives of MAGIC?

MAGIC's objectives include advancing the understanding of the causal factors for Type 2 diabetes, identifying new genetic markers, and ultimately developing improved preventive and managing strategies for the disease.

What type of studies does MAGIC conduct?

MAGIC conducts genetic association analyses on a wide variety of traits related to glucose metabolism from cohorts around the world. This includes both case-control study designs as well as family studies involving twins or siblings.

How does MAGIC perform its meta-analyses?

For each meta-analysis, data from different cohorts are harmonized using unified inclusion criteria so that they can be compared and combined into a single analysis. Once all data sets have been combined, various statistical methods are used to identify genetic associations with Type 2 diabetes or other important metabolic traits.

What other organizations has MAGIC collaborated with?

In addition to independent academic researchers, MAGIC has had several key collaborations with organizations such as DIAGRAM (Diabetes Genetics Replication And Meta Analysis), GIGC (Genetics in Insulin Resistance & Glycemia Collaborative), NORCCAP (Nordic Centre of Excellence in Clinical Chemistry), AMGC (Asian Metabolism Group Consortium).

How long has MAGIC been active for?

Since it was established in 2006, MAGIC has grown into one of the most successful research consortia in genetics and diabetes research, having published over two hundred papers in top journals such as Nature Genetics, Cell Metabolism and Nature Communications.

What resources does MAGIC provide for researchers?

One main resource provided by the consortium is its Database Repository which contains information on hundreds of genome wide association studies that have been conducted around the world for various metabolic pathways. It also provides useful tools for analyzing these data sets including detailed tutorial materials and software packages.

Besides research activities, what else does MAGIC do?

Apart from research activities, MAGIC also organizes workshops, seminars and online courses aimed at helping scientists understand how to use their available data more effectively in order to come up with novel insights related to Type 2 diabetes risk factors. Additionally they also host educational talks open to public audiences seeking better understanding about this important disorder.

Is there any other way I can become involved with considering or contributing to the work conducted by MAGIC?

Yes! Open opportunities exist for individuals interested in getting involved in some way. For example you could volunteer your time by conducting reviews for manuscripts submitted by authors collaborating with AGMC or providing technical support during one of their upcoming events such as their annual conference held every year. You could also contribute financially towards projects undertaken by members initiatives through donations or sponsorships.

Final Words:
The work done by the MAGIC consortium has led to over one hundred published research papers on genetic risk factors associated with type 2 diabetes over the past few years. These findings have improved our understanding of how certain gene variants contribute to the disease and have helped develop effective treatments tailored for people carrying those variants. With their ongoing research efforts, MAGIC continues its mission in finding new ways for preventing and managing type 2 diabetes in the years ahead.

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