What does POCC mean in CLINICAL MEDICINE

POCC stands for Proof of Clinical Concept and refers to the process of developing or validating a new clinical concept through small-scale clinical trial testing.

POCC is most commonly used when referring to early-stage trials that are designed to test the safety, efficacy, or other aspects of a novel medical concept or application.

The level and type of evidence needed for successful proof depends on many factors, including the nature and scope of the study, regulatory requirements, and existing data in related fields. Generally speaking, it should include findings from preclinical studies, biomarker information from patient samples, and early signs that indicate potential therapeutic effect in patients who have been treated with the proposed treatment.

Although both are considered early-phase studies meant to assess whether an intervention has promise in further research, there are some key differences between proof-of-concept studies and pilot studies. Proofs-of-concept generally involve fewer participants than pilot studies; they focus on demonstrating feasibility rather than collecting data about efficacy; and they often rely on newer scientific concepts or technologies that haven't had much prior testing.

The length of time needed for proof will vary depending on various factors such as scientific complexity, resources available, etc., but typically takes several years to complete all phases. Additionally some plans may extend beyond completion since further research may be needed if promising results are observed during initial trials.